Multiple roles of the SO2-42/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions

Meeyoung Park; Ehud Ohana; Soo Young Choi; Myeong Sok Lee; Jong Hoon Park; Shmuel Muallem

doi:https://doi.org/10.1074/jbc.M113.503466

Multiple roles of the SO^2-₄2/Cl^-/OH^- exchanger protein Slc26a2 in chondrocyte functions

Meeyoung Park, Ehud Ohana, Soo Young Choi, Myeong Sok Lee, Jong Hoon Park, Shmuel Muallem

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Slc26a2 is a SO^2-₄ transporter that is mutated in diastrophic dysplasia. The role of Slc26a2 in several chondrocyte functions is unknown. Results: Slc26a2 is activated by IGF-1 to regulate chondrocyte, proliferation, differentiation, proteoglycan synthesis, and size. Conclusion: Slc26a2 regulates multiple SO^2-₄-dependent and SO^2-₄-independent chondrocyte functions. Significance: The findings should help in understanding aberrant SLC26A2 function in diastrophic dysplasia.

Original language	American English
Pages (from-to)	1993-2001
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	289
Issue number	4
DOIs	https://doi.org/10.1074/jbc.M113.503466
State	Published - 24 Jan 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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https://doi.org/10.1074/jbc.M113.503466

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title = "Multiple roles of the SO2-42/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions",

abstract = "Background: Slc26a2 is a SO2-4 transporter that is mutated in diastrophic dysplasia. The role of Slc26a2 in several chondrocyte functions is unknown. Results: Slc26a2 is activated by IGF-1 to regulate chondrocyte, proliferation, differentiation, proteoglycan synthesis, and size. Conclusion: Slc26a2 regulates multiple SO2-4-dependent and SO2-4-independent chondrocyte functions. Significance: The findings should help in understanding aberrant SLC26A2 function in diastrophic dysplasia.",

author = "Meeyoung Park and Ehud Ohana and Choi, {Soo Young} and Lee, {Myeong Sok} and Park, {Jong Hoon} and Shmuel Muallem",

year = "2014",

month = jan,

day = "24",

doi = "https://doi.org/10.1074/jbc.M113.503466",

language = "American English",

volume = "289",

pages = "1993--2001",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

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T1 - Multiple roles of the SO2-42/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions

AU - Park, Meeyoung

AU - Ohana, Ehud

AU - Choi, Soo Young

AU - Lee, Myeong Sok

AU - Park, Jong Hoon

AU - Muallem, Shmuel

PY - 2014/1/24

Y1 - 2014/1/24

N2 - Background: Slc26a2 is a SO2-4 transporter that is mutated in diastrophic dysplasia. The role of Slc26a2 in several chondrocyte functions is unknown. Results: Slc26a2 is activated by IGF-1 to regulate chondrocyte, proliferation, differentiation, proteoglycan synthesis, and size. Conclusion: Slc26a2 regulates multiple SO2-4-dependent and SO2-4-independent chondrocyte functions. Significance: The findings should help in understanding aberrant SLC26A2 function in diastrophic dysplasia.

AB - Background: Slc26a2 is a SO2-4 transporter that is mutated in diastrophic dysplasia. The role of Slc26a2 in several chondrocyte functions is unknown. Results: Slc26a2 is activated by IGF-1 to regulate chondrocyte, proliferation, differentiation, proteoglycan synthesis, and size. Conclusion: Slc26a2 regulates multiple SO2-4-dependent and SO2-4-independent chondrocyte functions. Significance: The findings should help in understanding aberrant SLC26A2 function in diastrophic dysplasia.

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U2 - https://doi.org/10.1074/jbc.M113.503466

DO - https://doi.org/10.1074/jbc.M113.503466

M3 - Article

SN - 0021-9258

VL - 289

SP - 1993

EP - 2001

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 4

ER -

Multiple roles of the SO^2-₄2/Cl^-/OH^- exchanger protein Slc26a2 in chondrocyte functions

Abstract

All Science Journal Classification (ASJC) codes

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