Multimodal imaging of the amygdala in non-clinical subjects with high vs. low autistic-like social skills traits

Niccolò Zovetti, Tina Meller, Ulrika Evermann, Julia Katharina Pfarr, Jonas Hoffmann, Andrea Federspiel, Sebastian Walther, Sarah Grezellschak, Andreas Jansen, Ahmad Abu-Akel, Igor Nenadić

Research output: Contribution to journalArticlepeer-review

Abstract

Recent clinical and theoretical frameworks suggest that social skills and theory of mind impairments characteristic of autism spectrum disorder (ASD) are distributed in the general population on a continuum between healthy individuals and patients. The present multimodal study aimed at investigating the amygdala's function, perfusion, and volume in 56 non-clinical subjects from the general population with high (n = 28 High-SOC) or low (n = 28 Low-SOC) autistic-like social skills traits. Participants underwent magnetic resonance imaging to evaluate the amygdala's functional connectivity at rest, blood perfusion by means of arterial spin labelling, its activation during a face evaluation task and lastly grey matter volumes. The High-SOC group was characterised by higher blood perfusion in both amygdalae, lower volume of the left amygdala and higher activations of the right amygdala during processing of human faces with fearful value. Resting state analyses did not reveal any significant difference between the two groups. Overall, our results highlight the presence of overlapping morpho-functional alterations of the amygdala between healthy individuals and ASD patients confirming the importance of the amygdala in this disorder and in social and emotional processing. Our findings may help disentangle the neurobiological facets of ASD elucidating aetiology and the relationship between clinical symptomatology and neurobiology.

Original languageAmerican English
Article number111910
JournalPsychiatry Research - Neuroimaging
Early online date22 Oct 2024
DOIs
StatePublished - Jan 2025

Keywords

  • Amygdala
  • Autism
  • Autistic-like traits
  • Grey matter
  • Resting-state
  • fMRI

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

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