Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation

Rotem Engelman; Pnina Weisman-Shomer; Tamar Ziv; Jianqiang Xu; Elias S.J. Arnér; Moran Benhar

doi:10.1074/jbc.M112.433755

Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation

Rotem Engelman, Pnina Weisman-Shomer, Tamar Ziv, Jianqiang Xu, Elias S.J. Arnér, Moran Benhar

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: S-Nitrosylation may regulate 2-Cys peroxiredoxin systems to affect cellular metabolism of hydrogen peroxide. Results: Nitrosylation impeded the peroxiredoxin-1 catalytic cycle by directly inhibiting the activity of peroxiredoxin-1 and by interfering with the recycling of oxidized peroxiredoxin-1 by the thioredoxin system. Conclusion: Nitrosylation exerts multilevel control of the thioredoxin-peroxiredoxin system. Significance: Through its multiple effects on the thioredoxin-peroxiredoxin system, nitrosylation may influence cellular redox homeostasis.

Original language	English
Pages (from-to)	11312-11324
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M112.433755
State	Published - 19 Apr 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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title = "Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation",

abstract = "Background: S-Nitrosylation may regulate 2-Cys peroxiredoxin systems to affect cellular metabolism of hydrogen peroxide. Results: Nitrosylation impeded the peroxiredoxin-1 catalytic cycle by directly inhibiting the activity of peroxiredoxin-1 and by interfering with the recycling of oxidized peroxiredoxin-1 by the thioredoxin system. Conclusion: Nitrosylation exerts multilevel control of the thioredoxin-peroxiredoxin system. Significance: Through its multiple effects on the thioredoxin-peroxiredoxin system, nitrosylation may influence cellular redox homeostasis.",

author = "Rotem Engelman and Pnina Weisman-Shomer and Tamar Ziv and Jianqiang Xu and Arn{\'e}r, \{Elias S.J.\} and Moran Benhar",

year = "2013",

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doi = "10.1074/jbc.M112.433755",

language = "الإنجليزيّة",

volume = "288",

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T1 - Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation

AU - Engelman, Rotem

AU - Weisman-Shomer, Pnina

AU - Ziv, Tamar

AU - Xu, Jianqiang

AU - Arnér, Elias S.J.

AU - Benhar, Moran

PY - 2013/4/19

Y1 - 2013/4/19

N2 - Background: S-Nitrosylation may regulate 2-Cys peroxiredoxin systems to affect cellular metabolism of hydrogen peroxide. Results: Nitrosylation impeded the peroxiredoxin-1 catalytic cycle by directly inhibiting the activity of peroxiredoxin-1 and by interfering with the recycling of oxidized peroxiredoxin-1 by the thioredoxin system. Conclusion: Nitrosylation exerts multilevel control of the thioredoxin-peroxiredoxin system. Significance: Through its multiple effects on the thioredoxin-peroxiredoxin system, nitrosylation may influence cellular redox homeostasis.

AB - Background: S-Nitrosylation may regulate 2-Cys peroxiredoxin systems to affect cellular metabolism of hydrogen peroxide. Results: Nitrosylation impeded the peroxiredoxin-1 catalytic cycle by directly inhibiting the activity of peroxiredoxin-1 and by interfering with the recycling of oxidized peroxiredoxin-1 by the thioredoxin system. Conclusion: Nitrosylation exerts multilevel control of the thioredoxin-peroxiredoxin system. Significance: Through its multiple effects on the thioredoxin-peroxiredoxin system, nitrosylation may influence cellular redox homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=84876546405&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.433755

DO - 10.1074/jbc.M112.433755

M3 - مقالة

SN - 0021-9258

VL - 288

SP - 11312

EP - 11324

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 16

ER -

Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation

Abstract

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