Multi-photon imaging of amine-functionalized silica nanoparticles

Filipe Natalio, Anubha Kashyap, Steffen Lorenz, Hannes Kerschbaumer, Michael Dietzsch, Muhammad Nawaz Tahir, Heinz Duschner, Susanne Strand, Dennis Strand, Wolfgang Tremel

Research output: Contribution to journalArticlepeer-review


A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot (TM) CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e. g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.

Original languageEnglish
Pages (from-to)4680-4686
Number of pages7
Issue number15
StatePublished - 2012


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