Multi-photon imaging of amine-functionalized silica nanoparticles

Filipe Natalio; Anubha Kashyap; Steffen Lorenz; Hannes Kerschbaumer; Michael Dietzsch; Muhammad Nawaz Tahir; Heinz Duschner; Susanne Strand; Dennis Strand; Wolfgang Tremel

doi:https://doi.org/10.1039/c2nr30660c

Multi-photon imaging of amine-functionalized silica nanoparticles

Filipe Natalio, Anubha Kashyap, Steffen Lorenz, Hannes Kerschbaumer, Michael Dietzsch, Muhammad Nawaz Tahir, Heinz Duschner, Susanne Strand, Dennis Strand, Wolfgang Tremel

Scientific Archeology Unit

Weizmann Institute Of Science

Research output: Contribution to journal › Article › peer-review

Abstract

A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot (TM) CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e. g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.

Original language	English
Pages (from-to)	4680-4686
Number of pages	7
Journal	Nanoscale
Volume	4
Issue number	15
DOIs	https://doi.org/10.1039/c2nr30660c
State	Published - 2012

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title = "Multi-photon imaging of amine-functionalized silica nanoparticles",

abstract = "A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot (TM) CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e. g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.",

author = "Filipe Natalio and Anubha Kashyap and Steffen Lorenz and Hannes Kerschbaumer and Michael Dietzsch and Tahir, {Muhammad Nawaz} and Heinz Duschner and Susanne Strand and Dennis Strand and Wolfgang Tremel",

year = "2012",

doi = "https://doi.org/10.1039/c2nr30660c",

language = "الإنجليزيّة",

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TY - JOUR

T1 - Multi-photon imaging of amine-functionalized silica nanoparticles

AU - Natalio, Filipe

AU - Kashyap, Anubha

AU - Lorenz, Steffen

AU - Kerschbaumer, Hannes

AU - Dietzsch, Michael

AU - Tahir, Muhammad Nawaz

AU - Duschner, Heinz

AU - Strand, Susanne

AU - Strand, Dennis

AU - Tremel, Wolfgang

PY - 2012

Y1 - 2012

N2 - A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot (TM) CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e. g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.

AB - A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot (TM) CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e. g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.

U2 - https://doi.org/10.1039/c2nr30660c

DO - https://doi.org/10.1039/c2nr30660c

M3 - مقالة

SN - 2040-3364

VL - 4

SP - 4680

EP - 4686

JO - Nanoscale

JF - Nanoscale

IS - 15

ER -

Multi-photon imaging of amine-functionalized silica nanoparticles

Abstract

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