Mucoadhesive nanogels by ionotropic crosslinking of chitosan-g-oligo(NiPAam) polymeric micelles as novel drug nanocarriers

Maya Menaker Raskin, Inbar Schlachet, Alejandro Sosnik

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To investigate a novel kind of mucoadhesive nanogel based on the supramolecular aggregation of chitosan-g-oligo(N-isopropylacrylamide) copolymers. Materials & methods: Copolymers were synthesized by the graft-free radical polymerization of N-isopropylacrylamide on chitosan. The aggregation was studied by dynamic light scattering and nanoparticle tracking analysis (NTA), the nanostructure by transmission electron microscopy(TEM)/cryo-TEM, the mucoadhesiveness in vitro with mucin and the cytocompatibility in Caco2 cells. Results: Copolymers (36-74% w/w N-isopropylacrylamide content) showed critical micellar concentration between 2.0 and 40.0 × 10-3% w/v and micelles were nanometric and positively charged. Physical stabilization was achieved with ionotropic crosslinking. TEM/cryo-TEM revealed multimicellar aggregates with good mucoadhesion and cytocompatibility properties. Micellar systems (1-10% w/v) increased the solubility of efavirenz up to 1249-fold. Conclusion: Results support the potential of these nano-drug delivery systems for improved mucosal administration of hydrophobic drugs.

Original languageEnglish
Pages (from-to)217-233
Number of pages17
JournalNanomedicine
Volume11
Issue number3
DOIs
StatePublished - Feb 2016

Keywords

  • chitosan-g-oligo(NiPAam) copolymers
  • efavirenz encapsulation
  • mucoadhesive polymeric micelles
  • mucosal drug delivery
  • noncovalent corona crosslinking

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering
  • General Materials Science
  • Medicine (miscellaneous)

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