Motherisk Rounds: The Fetal Safety of Benzodiazepines: An Updated Meta-analysis

Ehijie Enato, Myla Moretti, Gideon Koren

Research output: Contribution to journalArticlepeer-review


Benzodiazepines are commonly used by women of reproductive age, and hence many pregnant women are exposed to them. An updated meta-analysis of their fetal safety synthesized nine studies with over one million pregnancies, yielding an odds ratio of 1.07 (95% CI 0.91 to 1.25). While benzodiazepines do not appear to increase teratogenic risk in general, case-controls suggest a twofold increased risk of oral cleft.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalJournal of Obstetrics and Gynaecology Canada
Issue number1
StatePublished - 2011
Externally publishedYes


  • Benzodiazepine
  • Malformation risk
  • Teratogenicity

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology


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