More thoughts on the whole organism challenge

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In 2002 I proposed a long-term “grand challenge” for the comprehensive and realistic modeling of biological systems, where we try to understand and analyze an entire system in detail, utilizing in the modeling effort all that is known about it. The proposal was to produce an interactive, dynamic, computerized model of an entire multi-cellular organism. Specifically, I suggested the C. elegans nematode, which is extremely complex despite its small size, but well-defined in terms of anatomy and genetics. In this talk I will review this challenge, and discuss some insights about its feasibility, based on some recent modeling efforts we have carried out, including the organogenesis of the pancreas, rat neural whisking, cancer tumor formation, and various projects regarding the C. elegans nematode worm.

Original languageEnglish
Title of host publicationComputational Methods in Systems Biology - 13th International Conference, CMSB 2015, Proceedings
EditorsOlivier Roux, Jérémie Bourdon
PublisherSpringer Verlag
ISBN (Print)9783319234007
StatePublished - 2015
Event13th International Conference on Computational Methods in Systems Biology, CMSB 2015 - Nantes, France
Duration: 16 Sep 201518 Sep 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9308

Conference

Conference13th International Conference on Computational Methods in Systems Biology, CMSB 2015
Country/TerritoryFrance
CityNantes
Period16/09/1518/09/15

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • General Computer Science

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