TY - GEN
T1 - More thoughts on the whole organism challenge
AU - Harel, David
N1 - Publisher Copyright: © Springer International Publishing Switzerland 2015.
PY - 2015
Y1 - 2015
N2 - In 2002 I proposed a long-term “grand challenge” for the comprehensive and realistic modeling of biological systems, where we try to understand and analyze an entire system in detail, utilizing in the modeling effort all that is known about it. The proposal was to produce an interactive, dynamic, computerized model of an entire multi-cellular organism. Specifically, I suggested the C. elegans nematode, which is extremely complex despite its small size, but well-defined in terms of anatomy and genetics. In this talk I will review this challenge, and discuss some insights about its feasibility, based on some recent modeling efforts we have carried out, including the organogenesis of the pancreas, rat neural whisking, cancer tumor formation, and various projects regarding the C. elegans nematode worm.
AB - In 2002 I proposed a long-term “grand challenge” for the comprehensive and realistic modeling of biological systems, where we try to understand and analyze an entire system in detail, utilizing in the modeling effort all that is known about it. The proposal was to produce an interactive, dynamic, computerized model of an entire multi-cellular organism. Specifically, I suggested the C. elegans nematode, which is extremely complex despite its small size, but well-defined in terms of anatomy and genetics. In this talk I will review this challenge, and discuss some insights about its feasibility, based on some recent modeling efforts we have carried out, including the organogenesis of the pancreas, rat neural whisking, cancer tumor formation, and various projects regarding the C. elegans nematode worm.
UR - http://www.scopus.com/inward/record.url?scp=84945913046&partnerID=8YFLogxK
M3 - منشور من مؤتمر
SN - 9783319234007
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
BT - Computational Methods in Systems Biology - 13th International Conference, CMSB 2015, Proceedings
A2 - Roux, Olivier
A2 - Bourdon, Jérémie
PB - Springer Verlag
T2 - 13th International Conference on Computational Methods in Systems Biology, CMSB 2015
Y2 - 16 September 2015 through 18 September 2015
ER -