Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Shlomit Guy; Dvir Rotem; Zvi Hayouka; Ronen Gabizon; Aviad Levin; Limor Zemel; Abraham Loyter; Danny Porath; Assaf Friedler

doi:10.1039/c3cc40748a

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Shlomit Guy, Dvir Rotem, Zvi Hayouka, Ronen Gabizon, Aviad Levin, Limor Zemel, Abraham Loyter, Danny Porath, Assaf Friedler

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

Original language	English
Pages (from-to)	3113-3115
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	30
DOIs	https://doi.org/10.1039/c3cc40748a
State	Published - 19 Mar 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc40748a

Cite this

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title = "Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system",

abstract = "Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.",

author = "Shlomit Guy and Dvir Rotem and Zvi Hayouka and Ronen Gabizon and Aviad Levin and Limor Zemel and Abraham Loyter and Danny Porath and Assaf Friedler",

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TY - JOUR

T1 - Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

AU - Guy, Shlomit

AU - Rotem, Dvir

AU - Hayouka, Zvi

AU - Gabizon, Ronen

AU - Levin, Aviad

AU - Zemel, Limor

AU - Loyter, Abraham

AU - Porath, Danny

AU - Friedler, Assaf

PY - 2013/3/19

Y1 - 2013/3/19

N2 - Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

AB - Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

UR - http://www.scopus.com/inward/record.url?scp=84876586957&partnerID=8YFLogxK

U2 - 10.1039/c3cc40748a

DO - 10.1039/c3cc40748a

M3 - مقالة

C2 - 23463374

SN - 1359-7345

VL - 49

SP - 3113

EP - 3115

JO - Chemical Communications

JF - Chemical Communications

IS - 30

ER -

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Abstract

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All Science Journal Classification (ASJC) codes

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