Abstract
Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes (T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in which this review focuses include amylin, Aβ tau and α-synuclein. Understanding the molecular mechanisms in which these amyloidogenic proteins interact with membranes is a challenging research to both experimental and computational studies. This review illustrates recent studies on amyloid-membrane interactions, but it mainly focuses on the challenge issues related to experimental techniques to investigate at the molecular level these interactions and provides thoughts and outlook for future computational studies.
| Original language | English |
|---|---|
| Pages (from-to) | 1889-1905 |
| Number of pages | 17 |
| Journal | Biochimica et Biophysica Acta - Biomembranes |
| Volume | 1860 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1 Sep 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Aggregation
- Amylin
- Amyloid β
- Molecular dynamics simulations
- Tau
- α-Synuclein
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Cell Biology
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