Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans

Jinchuan Hu; Christopher P. Selby; Sheera Adar; Ogun Adebali; Aziz Sancar

doi:10.1074/jbc.R117.807453

Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans

Jinchuan Hu, Christopher P. Selby, Sheera Adar, Ogun Adebali, Aziz Sancar

Department of Microbiology and Molecular Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Short survey › peer-review

Abstract

Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.

Original language	English
Pages (from-to)	15588-15597
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	292
Issue number	38
DOIs	https://doi.org/10.1074/jbc.R117.807453
State	Published - 22 Sep 2017

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.R117.807453

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abstract = "Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.",

author = "Jinchuan Hu and Selby, \{Christopher P.\} and Sheera Adar and Ogun Adebali and Aziz Sancar",

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AU - Selby, Christopher P.

AU - Adar, Sheera

AU - Adebali, Ogun

AU - Sancar, Aziz

PY - 2017/9/22

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AB - Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.

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SN - 0021-9258

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Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans

Abstract

All Science Journal Classification (ASJC) codes

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