TY - JOUR
T1 - Molecular Imaging of Healing After Myocardial Infarction
AU - Naresh, Nivedita K.
AU - Ben-Mordechai, Tamar
AU - Leor, Jonathan
AU - Epstein, Frederick H.
N1 - Funding Information: Acknowledgments Drs. Leor and Epstein acknowledge support from US-Israel Binational Science Foundation Grant 2007290. Dr. Epstein is also supported by NIH NIBIB R01 EB001763.
PY - 2011/2
Y1 - 2011/2
N2 - The progression from acute myocardial infarction (MI) to heart failure continues to be a major cause of morbidity and mortality. Potential new therapies for improved infarct healing such as stem cells, gene therapy, and tissue engineering are being investigated. Noninvasive imaging plays a central role in the evaluation of MI and infarct healing, both clinically and in preclinical research. Traditionally, imaging has been used to assess cardiac structure, function, perfusion, and viability. However, new imaging methods can be used to assess biological processes at the cellular and molecular level. We review molecular imaging techniques for evaluating the biology of infarct healing and repair. Specifically, we cover recent advances in imaging the various phases of MI and infarct healing such as apoptosis, inflammation, angiogenesis, extracellular matrix deposition, and scar formation. Significant progress has been made in preclinical molecular imaging, and future challenges include translation of these methods to clinical practice.
AB - The progression from acute myocardial infarction (MI) to heart failure continues to be a major cause of morbidity and mortality. Potential new therapies for improved infarct healing such as stem cells, gene therapy, and tissue engineering are being investigated. Noninvasive imaging plays a central role in the evaluation of MI and infarct healing, both clinically and in preclinical research. Traditionally, imaging has been used to assess cardiac structure, function, perfusion, and viability. However, new imaging methods can be used to assess biological processes at the cellular and molecular level. We review molecular imaging techniques for evaluating the biology of infarct healing and repair. Specifically, we cover recent advances in imaging the various phases of MI and infarct healing such as apoptosis, inflammation, angiogenesis, extracellular matrix deposition, and scar formation. Significant progress has been made in preclinical molecular imaging, and future challenges include translation of these methods to clinical practice.
KW - Infarct healing
KW - Molecular imaging
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=84857628062&partnerID=8YFLogxK
U2 - 10.1007/s12410-010-9058-0
DO - 10.1007/s12410-010-9058-0
M3 - مقالة مرجعية
SN - 1941-9066
VL - 4
SP - 63
EP - 76
JO - Current Cardiovascular Imaging Reports
JF - Current Cardiovascular Imaging Reports
IS - 1
ER -