Molecular Engineering of Nonmetallic Biosensors for CEST MRI

Amnon Bar-Shir, Jeff W. M. Bulte, Assaf A. Gilad

Research output: Contribution to journalReview articlepeer-review


Recent advancements in molecular and synthetic combined with synthetic chemistry and biotechnology, have opened up new opportunities to engineer-novel platforms that : can monitor complex biological processes with various noninvasive imaging modalities. After decades of using gadolinium- or iron, based metallic sensors for MRI, the recently developed chemical exchange saturation transfer (CEST) contrast mechanism has created an opportunity for rational design; in silico, of nonmetallic biosensors for MM. These biomolecules are either naturally, occurring compounds,(amino acids, sugars, nucleosides native proteins) Or can be artificially engineered (synthetic probes or recombinant proteins). They can be, administered either as,1 exogenous agents Or Can be genetically (over)expressed. Moreover, they can be precisely engineered to achieve the desired biochemical properties for fine tuning optimized imaging schemes. The availability of these agents marks the dawn of a new scientific era for molecular and cellular MRI.
Original languageEnglish
Pages (from-to)1160-1170
Number of pages11
JournalACS Chemical Biology
Issue number5
StatePublished - May 2015


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