Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Walter Dunn; Yuri Rassovsky; Jonathan K. Wynn; Allan D. Wu; Marco Iacoboni; Gerhard Hellemann; Michael F. Green

doi:10.1016/j.schres.2016.04.021

Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Walter Dunn
, Yuri Rassovsky
, Jonathan K. Wynn
, Allan D. Wu
, Marco Iacoboni
, Gerhard Hellemann
, Michael F. Green

Department of Psychology

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.

Original language	English GB
Pages (from-to)	189-191
Number of pages	3
Journal	Schizophrenia Research
Volume	174
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2016.04.021
State	Published - 1 Jul 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cognition
Mismatch negativity
Schizophrenia
Target engagement
Transcranial direct current stimulation
tDCS

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/j.schres.2016.04.021

Cite this

@article{439875789354435aa190e9cdcee23814,

title = "Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia",

abstract = "This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.",

keywords = "Cognition, Mismatch negativity, Schizophrenia, Target engagement, Transcranial direct current stimulation, tDCS",

author = "Walter Dunn and Yuri Rassovsky and Wynn, \{Jonathan K.\} and Wu, \{Allan D.\} and Marco Iacoboni and Gerhard Hellemann and Green, \{Michael F.\}",

note = "Publisher Copyright: {\textcopyright} 2016.",

year = "2016",

month = jul,

day = "1",

doi = "10.1016/j.schres.2016.04.021",

language = "الإنجليزيّة",

volume = "174",

pages = "189--191",

journal = "Schizophrenia Research",

issn = "0920-9964",

number = "1-3",

}

TY - JOUR

T1 - Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

AU - Dunn, Walter

AU - Rassovsky, Yuri

AU - Wynn, Jonathan K.

AU - Wu, Allan D.

AU - Iacoboni, Marco

AU - Hellemann, Gerhard

AU - Green, Michael F.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.

AB - This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.

KW - Cognition

KW - Mismatch negativity

KW - Schizophrenia

KW - Target engagement

KW - Transcranial direct current stimulation

KW - tDCS

UR - https://www.scopus.com/pages/publications/84964691843

U2 - 10.1016/j.schres.2016.04.021

DO - 10.1016/j.schres.2016.04.021

M3 - مقالة

C2 - 27132485

SN - 0920-9964

VL - 174

SP - 189

EP - 191

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this