Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements

Carmel Braverman-Gross; Nissim Benvenisty

doi:10.3389/fendo.2021.622940

Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements

Carmel Braverman-Gross, Nissim Benvenisty

Department of Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.

Original language	English
Article number	622940
Journal	Frontiers in Endocrinology
Volume	12
DOIs	https://doi.org/10.3389/fendo.2021.622940
State	Published - 22 Feb 2021

Keywords

disease modeling
genetic and epigenetic aberrations
human embryonic stem cells
induced pluripotent stem cells
maturity onset diabetes of the young

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fendo.2021.622940

Cite this

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title = "Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements",

abstract = "Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.",

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T2 - Challenges and Achievements

AU - Braverman-Gross, Carmel

AU - Benvenisty, Nissim

PY - 2021/2/22

Y1 - 2021/2/22

N2 - Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.

AB - Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.

KW - disease modeling

KW - genetic and epigenetic aberrations

KW - human embryonic stem cells

KW - induced pluripotent stem cells

KW - maturity onset diabetes of the young

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DO - 10.3389/fendo.2021.622940

M3 - مقالة مرجعية

SN - 1664-2392

VL - 12

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 622940

ER -

Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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