Modeling collective cell migration in geometric confinement

Victoria Tarle, Estelle Gauquelin, S. R. K. Vedula, Joseph D'Alessandro, C. T. Lim, Benoit Ladoux, Nir Gov

Research output: Contribution to journalArticlepeer-review

Abstract

Monolayer expansion has generated great interest as a model system to study collective cell migration. During such an expansion the culture front often develops 'fingers', which we have recently modeled using a proposed feedback between the curvature of the monolayer's leading edge and the outward motility of the edge cells. We show that this model is able to explain the puzzling observed increase of collective cellular migration speed of a monolayer expanding into thin stripes, as well as describe the behavior within different confining geometries that were recently observed in experiments. These comparisons give support to the model and emphasize the role played by the edge cells and the edge shape during collective cell motion.

Original languageEnglish
Article number035001
JournalPhysical Biology
Volume14
Issue number3
DOIs
StatePublished - 3 May 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biophysics
  • Structural Biology
  • Cell Biology

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