@article{7a112b0e5b9b42c5a77f4c279ebf00ae,
title = "Modeling collective cell migration in geometric confinement",
abstract = "Monolayer expansion has generated great interest as a model system to study collective cell migration. During such an expansion the culture front often develops 'fingers', which we have recently modeled using a proposed feedback between the curvature of the monolayer's leading edge and the outward motility of the edge cells. We show that this model is able to explain the puzzling observed increase of collective cellular migration speed of a monolayer expanding into thin stripes, as well as describe the behavior within different confining geometries that were recently observed in experiments. These comparisons give support to the model and emphasize the role played by the edge cells and the edge shape during collective cell motion.",
author = "Victoria Tarle and Estelle Gauquelin and Vedula, {S. R. K.} and Joseph D'Alessandro and Lim, {C. T.} and Benoit Ladoux and Nir Gov",
note = "ISF [580/12]; Human Frontier Science Program [RGP0040/2012]; European Research Council under the European Union / ERC [617233]; Mechanobiology InstituteNSG is the incumbent of the Lee and William Abramowitz Professorial Chair of Biophysics, and would like to thank also the ISF grant 580/12 for support. This work is made possible through the historic generosity of the Perlman family. The authors thank Man Chun Leong, group members from MBI and Institut Jacques Monod. Financial supports from the Human Frontier Science Program (grant RGP0040/2012 to BL), the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013 to BL) / ERC grant agreement n 617233 (to BL), and the Mechanobiology Institute (to CTL, BL) are gratefully acknowledged. NSG is the incumbent of the Lee and William Abramowitz Professorial Chair of Biophysics, and would like to thank also the ISF grant 580/12 for support. This work is made possible through the historic generosity of the Perlman family. The authors thank Man Chun Leong, group members from MBI and Institut Jacques Monod. Financial supports from the Human Frontier Science Program (grant RGP0040/2012 to BL), the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013 to BL) / ERC grant agreement n 617233 (to BL), and the Mechanobiology Institute (to CTL, BL) are gratefully acknowledged.",
year = "2017",
month = may,
day = "3",
doi = "10.1088/1478-3975/aa6591",
language = "الإنجليزيّة",
volume = "14",
journal = "Physical Biology",
issn = "1478-3967",
publisher = "IOP Publishing Ltd.",
number = "3",
}