Modeling-Based Response-Guided DAA Therapy for Chronic Hepatitis C to Identify Individuals for Shortening Treatment Duration

Ashish Goyal; Alex Churkin; Danny Barash; Scott J. Cotler; Amir Shlomai; Ohad Etzion; Harel Dahari

doi:10.1093/ofid/ofac157

Modeling-Based Response-Guided DAA Therapy for Chronic Hepatitis C to Identify Individuals for Shortening Treatment Duration

Ashish Goyal
, Alex Churkin
, Danny Barash
, Scott J. Cotler
, Amir Shlomai
, Ohad Etzion
, Harel Dahari

Ben-Gurion University of the Negev, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Shortening duration of direct-acting antiviral therapy for chronic hepatitis C could provide cost savings, reduce medication exposure, and foster adherence and treatment completion in special populations. The current analysis indicates that measuring hepatitis C virus at baseline and on days 7 and 14 of therapy can identify patients for shortening therapy duration.

Original language	English
Article number	ofac157
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	5
DOIs	https://doi.org/10.1093/ofid/ofac157
State	Published - 1 May 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Direct-acting antivirals
Hepatitis C virus
Mathematical modeling
Response-guided therapy
Time to cure

ASJC Scopus subject areas

Oncology
Infectious Diseases

Access to Document

10.1093/ofid/ofac157

Cite this

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title = "Modeling-Based Response-Guided DAA Therapy for Chronic Hepatitis C to Identify Individuals for Shortening Treatment Duration",

abstract = "Shortening duration of direct-acting antiviral therapy for chronic hepatitis C could provide cost savings, reduce medication exposure, and foster adherence and treatment completion in special populations. The current analysis indicates that measuring hepatitis C virus at baseline and on days 7 and 14 of therapy can identify patients for shortening therapy duration.",

keywords = "Direct-acting antivirals, Hepatitis C virus, Mathematical modeling, Response-guided therapy, Time to cure",

author = "Ashish Goyal and Alex Churkin and Danny Barash and Cotler, \{Scott J.\} and Amir Shlomai and Ohad Etzion and Harel Dahari",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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doi = "10.1093/ofid/ofac157",

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T1 - Modeling-Based Response-Guided DAA Therapy for Chronic Hepatitis C to Identify Individuals for Shortening Treatment Duration

AU - Goyal, Ashish

AU - Churkin, Alex

AU - Barash, Danny

AU - Cotler, Scott J.

AU - Shlomai, Amir

AU - Etzion, Ohad

AU - Dahari, Harel

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Shortening duration of direct-acting antiviral therapy for chronic hepatitis C could provide cost savings, reduce medication exposure, and foster adherence and treatment completion in special populations. The current analysis indicates that measuring hepatitis C virus at baseline and on days 7 and 14 of therapy can identify patients for shortening therapy duration.

AB - Shortening duration of direct-acting antiviral therapy for chronic hepatitis C could provide cost savings, reduce medication exposure, and foster adherence and treatment completion in special populations. The current analysis indicates that measuring hepatitis C virus at baseline and on days 7 and 14 of therapy can identify patients for shortening therapy duration.

KW - Direct-acting antivirals

KW - Hepatitis C virus

KW - Mathematical modeling

KW - Response-guided therapy

KW - Time to cure

UR - https://www.scopus.com/pages/publications/85130365120

U2 - 10.1093/ofid/ofac157

DO - 10.1093/ofid/ofac157

M3 - Article

C2 - 35493122

SN - 2328-8957

VL - 9

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 5

M1 - ofac157

ER -

Modeling-Based Response-Guided DAA Therapy for Chronic Hepatitis C to Identify Individuals for Shortening Treatment Duration

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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