Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility

Boaz Styr; Nir Gonen; Daniel Zarhin; Antonella Ruggiero; Refaela Atsmon; Neta Gazit; Gabriella Braun; Samuel Frere; Irena Vertkin; Ilana Shapira; Michal Harel; Leore R. Heim; Maxim Katsenelson; Ohad Rechnitz; Saja Fadila; Dori Derdikman; Moran Rubinstein; Tamar Geiger; Eytan Ruppin; Inna Slutsky

doi:10.1016/j.neuron.2019.03.045

Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility

Boaz Styr, Nir Gonen, Daniel Zarhin, Antonella Ruggiero, Refaela Atsmon, Neta Gazit, Gabriella Braun, Samuel Frere, Irena Vertkin, Ilana Shapira, Michal Harel, Leore R. Heim, Maxim Katsenelson, Ohad Rechnitz, Saja Fadila, Dori Derdikman, Moran Rubinstein, Tamar Geiger, Eytan Ruppin, Inna Slutsky

Tel Aviv University, Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Firing rate set-point regulation has puzzled researchers for decades. Our findings show that mitochondrial DHODH meets the criteria of a bone fide regulator of activity set points and suggest lowering firing set point as a new strategy to treat epilepsy.

Original language	English
Pages (from-to)	1009-1024.e8
Journal	Neuron
Volume	102
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2019.03.045
State	Published - 5 Jun 2019

Keywords

Dravet syndrome
calcium
dihydroorotate dehydrogenase
epilepsy
firing rate
hippocampus
homeostasis
mitochondria
neuronal metabolism
set point

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2019.03.045

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Styr, B., Gonen, N., Zarhin, D., Ruggiero, A., Atsmon, R., Gazit, N., Braun, G., Frere, S., Vertkin, I., Shapira, I., Harel, M., Heim, L. R., Katsenelson, M., Rechnitz, O., Fadila, S., Derdikman, D., Rubinstein, M., Geiger, T., Ruppin, E., & Slutsky, I. (2019). Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron, 102(5), 1009-1024.e8. https://doi.org/10.1016/j.neuron.2019.03.045

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title = "Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility",

abstract = "Firing rate set-point regulation has puzzled researchers for decades. Our findings show that mitochondrial DHODH meets the criteria of a bone fide regulator of activity set points and suggest lowering firing set point as a new strategy to treat epilepsy.",

keywords = "Dravet syndrome, calcium, dihydroorotate dehydrogenase, epilepsy, firing rate, hippocampus, homeostasis, mitochondria, neuronal metabolism, set point",

author = "Boaz Styr and Nir Gonen and Daniel Zarhin and Antonella Ruggiero and Refaela Atsmon and Neta Gazit and Gabriella Braun and Samuel Frere and Irena Vertkin and Ilana Shapira and Michal Harel and Heim, {Leore R.} and Maxim Katsenelson and Ohad Rechnitz and Saja Fadila and Dori Derdikman and Moran Rubinstein and Tamar Geiger and Eytan Ruppin and Inna Slutsky",

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doi = "10.1016/j.neuron.2019.03.045",

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Styr, B, Gonen, N, Zarhin, D, Ruggiero, A, Atsmon, R, Gazit, N, Braun, G, Frere, S, Vertkin, I, Shapira, I, Harel, M, Heim, LR, Katsenelson, M, Rechnitz, O, Fadila, S, Derdikman, D , Rubinstein, M , Geiger, T, Ruppin, E & Slutsky, I 2019, 'Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility', Neuron, vol. 102, no. 5, pp. 1009-1024.e8. https://doi.org/10.1016/j.neuron.2019.03.045

TY - JOUR

T1 - Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility

AU - Styr, Boaz

AU - Gonen, Nir

AU - Zarhin, Daniel

AU - Ruggiero, Antonella

AU - Atsmon, Refaela

AU - Gazit, Neta

AU - Braun, Gabriella

AU - Frere, Samuel

AU - Vertkin, Irena

AU - Shapira, Ilana

AU - Harel, Michal

AU - Heim, Leore R.

AU - Katsenelson, Maxim

AU - Rechnitz, Ohad

AU - Fadila, Saja

AU - Derdikman, Dori

AU - Rubinstein, Moran

AU - Geiger, Tamar

AU - Ruppin, Eytan

AU - Slutsky, Inna

PY - 2019/6/5

Y1 - 2019/6/5

N2 - Firing rate set-point regulation has puzzled researchers for decades. Our findings show that mitochondrial DHODH meets the criteria of a bone fide regulator of activity set points and suggest lowering firing set point as a new strategy to treat epilepsy.

AB - Firing rate set-point regulation has puzzled researchers for decades. Our findings show that mitochondrial DHODH meets the criteria of a bone fide regulator of activity set points and suggest lowering firing set point as a new strategy to treat epilepsy.

KW - Dravet syndrome

KW - calcium

KW - dihydroorotate dehydrogenase

KW - epilepsy

KW - firing rate

KW - hippocampus

KW - homeostasis

KW - mitochondria

KW - neuronal metabolism

KW - set point

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U2 - 10.1016/j.neuron.2019.03.045

DO - 10.1016/j.neuron.2019.03.045

M3 - مقالة

C2 - 31047779

SN - 0896-6273

VL - 102

SP - 1009-1024.e8

JO - Neuron

JF - Neuron

IS - 5

ER -

Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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