Mitochondrial reactive oxygen species at The heart of The matter: New therapeutic approaches for cardiovascular diseases

Opher S. Kornfeld; Sunhee Hwang; Marie Hélène Disatnik; Che Hong Chen; Nir Qvit; Daria Mochly-Rosen

doi:10.1161/CIRCRESAHA.116.305432

Mitochondrial reactive oxygen species at The heart of The matter: New therapeutic approaches for cardiovascular diseases

Opher S. Kornfeld, Sunhee Hwang, Marie Hélène Disatnik, Che Hong Chen, Nir Qvit, Daria Mochly-Rosen

Research output: Contribution to journal › Review article › peer-review

Abstract

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into The clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge The traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.

Original language	English
Pages (from-to)	1783-1799
Number of pages	17
Journal	Circulation Research
Volume	116
Issue number	11
DOIs	https://doi.org/10.1161/CIRCRESAHA.116.305432
State	Published - 22 May 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

mitochondria
mitochondrial degradation
mitochondrial dynamics
protein kinase C
reactive oxygen species

All Science Journal Classification (ASJC) codes

Physiology
Cardiology and Cardiovascular Medicine

Access to Document

10.1161/CIRCRESAHA.116.305432

Cite this

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title = "Mitochondrial reactive oxygen species at The heart of The matter: New therapeutic approaches for cardiovascular diseases",

abstract = "Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into The clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge The traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.",

keywords = "mitochondria, mitochondrial degradation, mitochondrial dynamics, protein kinase C, reactive oxygen species",

author = "Kornfeld, \{Opher S.\} and Sunhee Hwang and Disatnik, \{Marie H{\'e}l{\`e}ne\} and Chen, \{Che Hong\} and Nir Qvit and Daria Mochly-Rosen",

note = "Publisher Copyright: {\textcopyright} 2015 American Heart Association, Inc.",

year = "2015",

month = may,

day = "22",

doi = "10.1161/CIRCRESAHA.116.305432",

language = "الإنجليزيّة",

volume = "116",

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issn = "0009-7330",

publisher = "Lippincott Williams and Wilkins",

number = "11",

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TY - JOUR

T1 - Mitochondrial reactive oxygen species at The heart of The matter

T2 - New therapeutic approaches for cardiovascular diseases

AU - Kornfeld, Opher S.

AU - Hwang, Sunhee

AU - Disatnik, Marie Hélène

AU - Chen, Che Hong

AU - Qvit, Nir

AU - Mochly-Rosen, Daria

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into The clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge The traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.

AB - Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into The clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge The traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.

KW - mitochondria

KW - mitochondrial degradation

KW - mitochondrial dynamics

KW - protein kinase C

KW - reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=84942777656&partnerID=8YFLogxK

U2 - 10.1161/CIRCRESAHA.116.305432

DO - 10.1161/CIRCRESAHA.116.305432

M3 - مقالة مرجعية

C2 - 25999419

SN - 0009-7330

VL - 116

SP - 1783

EP - 1799

JO - Circulation Research

JF - Circulation Research

IS - 11

ER -

Mitochondrial reactive oxygen species at The heart of The matter: New therapeutic approaches for cardiovascular diseases

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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