@article{3ece54343a8547b0895c943b87577b9b,
title = "Mitochondrial carrier homolog 2 is necessary for AML survival",
abstract = "Through a clustered regularly insterspaced short palindromic repeats (CRISPR) screen to identify mitochondrial genes necessary for the growth of acute myeloid leukemia (AML) cells, we identified the mitochondrial outer membrane protein mitochondrial carrier homolog 2 (MTCH2). In AML, knockdown of MTCH2 decreased growth, reduced engraftment potential of stem cells, and induced differentiation. Inhibiting MTCH2 in AML cells increased nuclear pyruvate and pyruvate dehydrogenase (PDH), which induced histone acetylation and subsequently promoted the differentiation of AML cells. Thus, we have defined a new mechanism by which mitochondria and metabolism regulate AML stem cells and gene expression.",
author = "Khan, {Dilshad H} and Michael Mullokandov and Yan Wu and Veronique Voisin and Gronda, {Marcela Victoria} and Rose Hurren and Xiaoming Wang and Neil MacLean and Jeyaraju, {Danny V} and Yulia Jitkova and Xu, {G Wei} and Laister, {Rob C} and Ayesh Seneviratne and Zachary Blatman and Troy Ketala and Bader, {Gary D} and Marhon, {Sajid A} and Carvalho, {Daniel D De} and Minden, {Mark D} and Atan Gross and Schimmer, {Aaron D}",
note = "We thank Jill Flewelling (Princess Margaret Cancer Centre) for administrative assistance. We thank Shai Izraeli (Tel Aviv University) for helping initiate the project. This work was supported by the Canadian Institutes of Health Research, the Ontario Institute for Cancer Research with funding provided by the Ontario Ministry of Research and Innovation, the Princess Margaret Cancer Centre Foundation, and the Ministry of Long Term Health and Planning in the Province of Ontario. DHK was supported by a fellowship from the Leukemia and Lymphoma Society of Canada. ADS holds the Barbara Baker Chair in Leukemia and Related Diseases. Author contributions - D.H.K: conception and design, execution, collection, and or assembly of data, data analysis, interpretation, manuscript writing; M.M., Y.W., V.V., M.G., R.H., X.W., N.M., D.V.J., Y.J., G.W.X, R.L., A.S., Z.B., T.K., G.B., S.A.M., D.D.C., M.M., A.G: collection and/or/assembly of data, data analysis, and interpretation. A.D.S: conception and Downloaded from https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2019000106/1724578/blood.2019000106.pdf by WEIZMANN INST user on 11 May 2020 design, financial support, collection and/or assembly of data, data analysis and interpretation, manuscript writing, final approval of the manuscript.",
year = "2020",
month = jul,
day = "2",
doi = "https://doi.org/10.1182/blood.2019000106",
language = "الإنجليزيّة",
volume = "136",
pages = "81--92",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "1",
}