MiRNAs at the interface of cellular stress and disease

Anna Emde; Eran Hornstein

doi:10.15252/embj.201488142

MiRNAs at the interface of cellular stress and disease

Anna Emde, Eran Hornstein

Department of Molecular Genetics

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.

Original language	English
Pages (from-to)	1428-1437
Number of pages	10
Journal	EMBO Journal
Volume	33
Issue number	13
DOIs	https://doi.org/10.15252/embj.201488142
State	Published - 2014

All Science Journal Classification (ASJC) codes

General Immunology and Microbiology
General Biochemistry,Genetics and Molecular Biology
Molecular Biology
General Neuroscience

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10.15252/embj.201488142

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title = "MiRNAs at the interface of cellular stress and disease",

abstract = "microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.",

author = "Anna Emde and Eran Hornstein",

note = "ERC consolidator program; Israel Science Foundation; Bruno Frick foundation; Kekst Family Institute for Medical Genetics; David and Fela Shapell Family Center for Genetic Disorders Research; Crown Human Genome Center; Yeda Sela Center; Nella and Leon Benoziyo Center for Neurological Diseases; Y. Leon Benoziyo Institute for Molecular Medicine; Helen and Martin Kimmel Institute for Stem Cell Research; Nathan; Shirley; Philip and Charlene Vener New Scientist Fund; Julius and Ray Charlestein Foundation; Celia Benattar Memorial Fund for Juvenile Diabetes; Fraida Foundation; Wolfson Family Charitable Trust; Legacy Heritage Fund; Adelis Foundation; Minna-James-Heineman Stiftung; MERCK UK; Maria Halphen; Estates of Fannie Sherr; Lola Asseof; Lilly Fulop; Yeda-Sela fund Yeda-CEO fund; Teva NNE program; miCure Therapeutics; Deutsche Forschungsgemeinschaft (DFG)",

year = "2014",

doi = "10.15252/embj.201488142",

language = "الإنجليزيّة",

volume = "33",

pages = "1428--1437",

journal = "EMBO Journal",

issn = "0261-4189",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "13",

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TY - JOUR

T1 - MiRNAs at the interface of cellular stress and disease

AU - Emde, Anna

AU - Hornstein, Eran

N1 - ERC consolidator program; Israel Science Foundation; Bruno Frick foundation; Kekst Family Institute for Medical Genetics; David and Fela Shapell Family Center for Genetic Disorders Research; Crown Human Genome Center; Yeda Sela Center; Nella and Leon Benoziyo Center for Neurological Diseases; Y. Leon Benoziyo Institute for Molecular Medicine; Helen and Martin Kimmel Institute for Stem Cell Research; Nathan; Shirley; Philip and Charlene Vener New Scientist Fund; Julius and Ray Charlestein Foundation; Celia Benattar Memorial Fund for Juvenile Diabetes; Fraida Foundation; Wolfson Family Charitable Trust; Legacy Heritage Fund; Adelis Foundation; Minna-James-Heineman Stiftung; MERCK UK; Maria Halphen; Estates of Fannie Sherr; Lola Asseof; Lilly Fulop; Yeda-Sela fund Yeda-CEO fund; Teva NNE program; miCure Therapeutics; Deutsche Forschungsgemeinschaft (DFG)

PY - 2014

Y1 - 2014

N2 - microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.

AB - microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.

UR - http://www.scopus.com/inward/record.url?scp=84903704243&partnerID=8YFLogxK

U2 - 10.15252/embj.201488142

DO - 10.15252/embj.201488142

M3 - مقالة مرجعية

SN - 0261-4189

VL - 33

SP - 1428

EP - 1437

JO - EMBO Journal

JF - EMBO Journal

IS - 13

ER -

MiRNAs at the interface of cellular stress and disease

Abstract

All Science Journal Classification (ASJC) codes

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