MiRNAs at the interface of cellular stress and disease

Anna Emde, Eran Hornstein

Research output: Contribution to journalReview articlepeer-review

Abstract

microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.

Original languageEnglish
Pages (from-to)1428-1437
Number of pages10
JournalEMBO Journal
Volume33
Issue number13
DOIs
StatePublished - 2014

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • General Biochemistry,Genetics and Molecular Biology
  • Molecular Biology
  • General Neuroscience

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