@article{4631a50d54684a71bdc7de28a853fe08,
title = "MiRNAs at the interface of cellular stress and disease",
abstract = "microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.",
author = "Anna Emde and Eran Hornstein",
note = "ERC consolidator program; Israel Science Foundation; Bruno Frick foundation; Kekst Family Institute for Medical Genetics; David and Fela Shapell Family Center for Genetic Disorders Research; Crown Human Genome Center; Yeda Sela Center; Nella and Leon Benoziyo Center for Neurological Diseases; Y. Leon Benoziyo Institute for Molecular Medicine; Helen and Martin Kimmel Institute for Stem Cell Research; Nathan; Shirley; Philip and Charlene Vener New Scientist Fund; Julius and Ray Charlestein Foundation; Celia Benattar Memorial Fund for Juvenile Diabetes; Fraida Foundation; Wolfson Family Charitable Trust; Legacy Heritage Fund; Adelis Foundation; Minna-James-Heineman Stiftung; MERCK UK; Maria Halphen; Estates of Fannie Sherr; Lola Asseof; Lilly Fulop; Yeda-Sela fund Yeda-CEO fund; Teva NNE program; miCure Therapeutics; Deutsche Forschungsgemeinschaft (DFG)",
year = "2014",
doi = "10.15252/embj.201488142",
language = "الإنجليزيّة",
volume = "33",
pages = "1428--1437",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "13",
}