TY - CHAP
T1 - MiRNA expression and functions in glioma and glioma stem cells
AU - Brodie, Chaya
AU - Buchris, Efrat
AU - Lee, Hae Kyung
N1 - Publisher Copyright: © Springer International Publishing Switzerland 2014. All rights reserved.
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Glioblastoma (GBMs) are the most common and aggressive primary brain tumors. Current treatments include surgery, radiation therapy, and chemotherapy. Unfortunately, prognosis remains extremely poor and the median survival of 12-14 months in GBM has not changed significantly. GBMs contain a small subpopulation of glioma stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence. Thus, the development of new therapeutic strategies to target these cells is of utmost significance. MicroRNAs (miRNAs) have been reported to play a major role in cancer development and progression and are now emerge as potential therapeutic targets in various tumors. This chapter reviews the expression of miRNAs in GBM and GSCs and their use as diagnostic and prognostic biomarkers and discusses the role of specific miRNAs in GSC functions and their potential use as therapeutic targets. Since the clinical use of miRNAs is hindered by lack of effective delivery mechanisms to tumor sites, a particular focus is placed on the possible modes of delivery of miRNA mimics or antagonists focusing on viral vectors, nanoparticles, exosomes and stem cells.
AB - Glioblastoma (GBMs) are the most common and aggressive primary brain tumors. Current treatments include surgery, radiation therapy, and chemotherapy. Unfortunately, prognosis remains extremely poor and the median survival of 12-14 months in GBM has not changed significantly. GBMs contain a small subpopulation of glioma stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence. Thus, the development of new therapeutic strategies to target these cells is of utmost significance. MicroRNAs (miRNAs) have been reported to play a major role in cancer development and progression and are now emerge as potential therapeutic targets in various tumors. This chapter reviews the expression of miRNAs in GBM and GSCs and their use as diagnostic and prognostic biomarkers and discusses the role of specific miRNAs in GSC functions and their potential use as therapeutic targets. Since the clinical use of miRNAs is hindered by lack of effective delivery mechanisms to tumor sites, a particular focus is placed on the possible modes of delivery of miRNA mimics or antagonists focusing on viral vectors, nanoparticles, exosomes and stem cells.
UR - http://www.scopus.com/inward/record.url?scp=84930065061&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/978-3-319-05134-5_2
DO - https://doi.org/10.1007/978-3-319-05134-5_2
M3 - فصل
SN - 3319051334
SN - 9783319051338
SP - 29
EP - 49
BT - MicroRNA Targeted Cancer Therapy
ER -
