miR-184 represses β-catenin and behaves as a skin tumor suppressor

Lubov Turovsky, Ghazal Kheshaiboun, Gharam Yassen, Sara Nagosa, Ilanit Boyango, Aya Amitai-Lange, Swarnabh Bhattacharya, Neta Ilan, Israel Vlodavsky, Daniel Aberdam, Ruby Shalom-Feuerstein, Emily Avitan-Hersh

Research output: Contribution to journalArticlepeer-review


miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.

Original languageEnglish
Article number174
Pages (from-to)174
JournalCell Death and Disease
Issue number2
StatePublished - 26 Feb 2024


  • Animals
  • Carcinogenesis/genetics
  • Carcinoma, Squamous Cell/pathology
  • Cell Line, Tumor
  • Cell Movement/genetics
  • Cell Proliferation/genetics
  • Gene Expression Regulation, Neoplastic/genetics
  • Humans
  • Mice
  • MicroRNAs/genetics
  • Skin Neoplasms/genetics
  • beta Catenin/genetics

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cancer Research
  • Cell Biology
  • Immunology


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