Mind the Organelle Gap - Peroxisome Contact Sites in Disease

Ines Gomes Castro, Maya Schuldiner, Einat Zalckvar

Research output: Contribution to journalReview articlepeer-review


The eukaryotic cell is organized as a complex grid system where membrane-bound cellular compartments, organelles, must be localized to the right place at the right time. One way to facilitate correct organelle localization and organelle cooperation is through membrane contact sites, areas of close proximity between two organelles that are bridged by protein/lipid complexes. It is now clear that all organelles physically contact each other. The main focus of this review is contact sites of peroxisomes, central metabolic hubs whose defects lead to a variety of diseases. New peroxisome contacts, their tethering complexes and functions have been recently discovered. However, if and how peroxisome contacts contribute to the development of peroxisome-related diseases is still a mystery.

Original languageEnglish
Pages (from-to)199-210
Number of pages12
JournalTrends in Biochemical Sciences
Issue number3
StatePublished - Mar 2018


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