MIF- and CD74-Dependent Mechanisms

Shirly Becker-Herman; Naama Gil; Lihi Radomir; Idit Shachar

doi:10.1007/978-3-319-52354-5_1

MIF- and CD74-Dependent Mechanisms

Shirly Becker-Herman
, Naama Gil
, Lihi Radomir
, Idit Shachar

Department of Systems Immunology

Weizmann Institute of Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

CD74 is a type II cell surface protein that was previously shown to play a role in antigen presentation and as a receptor for the cytokine macrophage migration inhibitory factor (MIF). Studies from recent years demonstrate an important role for CD74 in maintenance of innate and adaptive immune cells. This chapter discusses the MIF/CD74-dependent role in regulating cell survival, metabolism, adhesion, and response to hypoxia in health and disease.

Original language	English GB
Title of host publication	MIF Family Cytokines in Innate Immunity and Homeostasis
Pages	1-20
Number of pages	20
ISBN (Electronic)	3319523546
DOIs	https://doi.org/10.1007/978-3-319-52354-5_1
State	Published - 13 Jun 2017

Publication series

Name	Progress in Inflammation Research

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10.1007/978-3-319-52354-5_1

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title = "MIF- and CD74-Dependent Mechanisms",

abstract = "CD74 is a type II cell surface protein that was previously shown to play a role in antigen presentation and as a receptor for the cytokine macrophage migration inhibitory factor (MIF). Studies from recent years demonstrate an important role for CD74 in maintenance of innate and adaptive immune cells. This chapter discusses the MIF/CD74-dependent role in regulating cell survival, metabolism, adhesion, and response to hypoxia in health and disease. ",

author = "Shirly Becker-Herman and Naama Gil and Lihi Radomir and Idit Shachar",

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AU - Gil, Naama

AU - Radomir, Lihi

AU - Shachar, Idit

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AB - CD74 is a type II cell surface protein that was previously shown to play a role in antigen presentation and as a receptor for the cytokine macrophage migration inhibitory factor (MIF). Studies from recent years demonstrate an important role for CD74 in maintenance of innate and adaptive immune cells. This chapter discusses the MIF/CD74-dependent role in regulating cell survival, metabolism, adhesion, and response to hypoxia in health and disease.

U2 - 10.1007/978-3-319-52354-5_1

DO - 10.1007/978-3-319-52354-5_1

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EP - 20

BT - MIF Family Cytokines in Innate Immunity and Homeostasis

ER -

MIF- and CD74-Dependent Mechanisms

Abstract

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