Abstract
In healthy individuals, the pool of peripheral lymphocytes is constant in size. The control of lymphoid homeostasis is the result of a very fine balance between lymphocyte production, survival and proliferation. Survival factors have been shown to play a critical role in maintaining the correct size of lymphocyte populations. Midkine, a heparin-binding cytokine was recently shown to be involved in cell proliferation, differentiation and apoptosis in various cell types including normal and malignant B cells. This review focuses on the role of midkine in the regulation of peripheral B cell survival in health and disease.
Original language | English |
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Pages (from-to) | 888-895 |
Number of pages | 8 |
Journal | British Journal of Pharmacology |
Volume | 171 |
Issue number | 4 |
DOIs | |
State | Published - Feb 2014 |
All Science Journal Classification (ASJC) codes
- Pharmacology