Midkine as a regulator of B cell survival in health and disease

Sivan Cohen, Idit Shachar

Research output: Contribution to journalReview articlepeer-review

Abstract

In healthy individuals, the pool of peripheral lymphocytes is constant in size. The control of lymphoid homeostasis is the result of a very fine balance between lymphocyte production, survival and proliferation. Survival factors have been shown to play a critical role in maintaining the correct size of lymphocyte populations. Midkine, a heparin-binding cytokine was recently shown to be involved in cell proliferation, differentiation and apoptosis in various cell types including normal and malignant B cells. This review focuses on the role of midkine in the regulation of peripheral B cell survival in health and disease.

Original languageEnglish
Pages (from-to)888-895
Number of pages8
JournalBritish Journal of Pharmacology
Volume171
Issue number4
DOIs
StatePublished - Feb 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology

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