MicroRNAS FOR THE GENERATION OF ASTROCYTES

Chaya Brodie (Inventor), Aharon Brodie (Inventor)

Research output: Patent

Abstract

A method of generating a population of cells useful for treating a nerve disease or disorder in a subject, the method comprising up-regulating a level of at least one exogenous miRNA in mesenchymal stem cells (MSCs) and/or down-regulating a level of at least one miRNA using a polynucleotide agent that hybridizes to the miRNA, thereby generating the population of cells useful for treating the nerve disease or disorder. Isolated populations of cells with an astrocytic phenotype generated thereby and uses thereof are also provided.
Original languageEnglish
Patent numberUS20190015453A1
StatePublished - 17 Jan 2019

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