MicroRNA pharmacogenomics: Post-transcriptional regulation of drug response

Jakob Lewin Rukov, Noam Shomron

Research output: Contribution to journalReview articlepeer-review


The field of pharmacogenomics aims to predict which drugs will be most effective and safe for a particular individual based on their genome sequence or expression profile, thereby allowing personalized treatment. The bulk of pharmacogenomic research has focused on the role of single nucleotide polymorphisms, copy number variations or differences in gene expression levels of drug metabolizing or transporting genes and drug targets. In this review paper, we focus instead on microRNAs (miRNAs): small noncoding RNAs, prevalent in metazoans, that negatively regulate gene expression in many cellular processes. We discuss how miRNAs, by regulating the expression of pharmacogenomic-related genes, can play a pivotal role in drug efficacy and toxicity and have potential clinical implications for personalized medicine.

Original languageEnglish
Pages (from-to)412-423
Number of pages12
JournalTrends in Molecular Medicine
Issue number8
StatePublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology


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