Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties

Yanina Minaberry; Diego A. Chiappetta; Alejandro Sosnik; Matías Jobbágy

doi:https://doi.org/10.1021/bm300814h

Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties

Yanina Minaberry, Diego A. Chiappetta, Alejandro Sosnik, Matías Jobbágy

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Biomacromolecules
Volume	14
Issue number	1
DOIs	https://doi.org/10.1021/bm300814h
State	Published - 14 Jan 2013

All Science Journal Classification (ASJC) codes

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

Access to Document

https://doi.org/10.1021/bm300814h

Cite this

@article{59bb4028c40b4ac18dd7df01de7a02ab,

title = "Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties",

abstract = "Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection.",

author = "Yanina Minaberry and Chiappetta, {Diego A.} and Alejandro Sosnik and Mat{\'i}as Jobb{\'a}gy",

year = "2013",

month = jan,

day = "14",

doi = "https://doi.org/10.1021/bm300814h",

language = "الإنجليزيّة",

volume = "14",

pages = "1--9",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties

AU - Minaberry, Yanina

AU - Chiappetta, Diego A.

AU - Sosnik, Alejandro

AU - Jobbágy, Matías

PY - 2013/1/14

Y1 - 2013/1/14

N2 - Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection.

AB - Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection.

UR - http://www.scopus.com/inward/record.url?scp=84872576682&partnerID=8YFLogxK

U2 - https://doi.org/10.1021/bm300814h

DO - https://doi.org/10.1021/bm300814h

M3 - مقالة

SN - 1525-7797

VL - 14

SP - 1

EP - 9

JO - Biomacromolecules

JF - Biomacromolecules

IS - 1

ER -

Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this