Microglia states and nomenclature: A field at its crossroads

Rosa C. Paolicelli; Amanda Sierra; Beth Stevens; Marie-Eve Tremblay; Adriano Aguzzi; Bahareh Ajami; Ido Amit; Etienne Audinat; Ingo Bechmann; Mariko Bennett; Frederick Bennett; Alain Bessis; Knut Biber; Staci Bilbo; Mathew Blurton-Jones; Erik Boddeke; Dora Brites; Bert Brône; Guy C. Brown; Oleg Butovsky; Monica J. Carson; Bernardo Castellano; Marco Colonna; Sally A. Cowley; Colm Cunningham; Dimitrios Davalos; Philip L. De Jager; Bart de Strooper; Adam Denes; Bart J.L. Eggen; Ukpong Eyo; Elena Galea; Sonia Garel; Florent Ginhoux; Christopher K. Glass; Ozgun Gokce; Diego Gomez-Nicola; Berta González; Siamon Gordon; Manuel B. Graeber; Andrew D. Greenhalgh; Pierre Gressens; Melanie Greter; David H. Gutmann; Christian Haass; Michael T. Heneka; Frank L. Heppner; Soyon Hong; David A. Hume; Steffen Jung; Helmut Kettenmann; Jonathan Kipnis; Ryuta Koyama; Greg Lemke; Marina Lynch; Ania Majewska; Marzia Malcangio; Tarja Malm; Renzo Mancuso; Takahiro Masuda; Michela Matteoli; Barry W. McColl; Veronique E. Miron; Anna Victoria Molofsky; Michelle Monje; Eva Mracsko; Agnes Nadjar; Jonas J. Neher; Urte Neniskyte; Harald Neumann; Mami Noda; Bo Peng; Francesca Peri; V. Hugh Perry; Phillip G. Popovich; Clare Pridans; Josef Priller; Marco Prinz; Davide Ragozzino; Richard M. Ransohoff; Michael W. Salter; Anne Schaefer; Dorothy P. Schafer; Michal Schwartz; Mikael Simons; Cody J. Smith; Wolfgang J. Streit; Tuan Leng Tay; Li-Huei Tsai; Alexei Verkhratsky; Rommy von Bernhardi; Hiroaki Wake; Valérie Wittamer; Susanne A. Wolf; Long-Jun Wu; Tony Wyss-Coray

doi:10.1016/j.neuron.2022.10.020

Microglia states and nomenclature: A field at its crossroads

Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brône, Guy C. Brown, Oleg ButovskyMonica J. Carson, Bernardo Castellano, Marco Colonna, Sally A. Cowley, Colm Cunningham, Dimitrios Davalos, Philip L. De Jager, Bart de Strooper, Adam Denes, Bart J.L. Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K. Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta González, Siamon Gordon, Manuel B. Graeber, Andrew D. Greenhalgh, Pierre Gressens, Melanie Greter, David H. Gutmann, Christian Haass, Michael T. Heneka, Frank L. Heppner, Soyon Hong, David A. Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W. McColl, Veronique E. Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J. Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V. Hugh Perry, Phillip G. Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M. Ransohoff, Michael W. Salter, Anne Schaefer, Dorothy P. Schafer, Michal Schwartz, Mikael Simons, Cody J. Smith, Wolfgang J. Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valérie Wittamer, Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as “resting versus activated” and “M1 versus M2.” This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.

Original language	English
Pages (from-to)	3458-3483
Number of pages	26
Journal	Neuron
Volume	110
Issue number	21
DOIs	https://doi.org/10.1016/j.neuron.2022.10.020
State	Published - 2 Nov 2022

All Science Journal Classification (ASJC) codes

General Neuroscience

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Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brône, B., Brown, G. C., ... Wyss-Coray, T. (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110(21), 3458-3483. https://doi.org/10.1016/j.neuron.2022.10.020

@article{f6020e5d8ceb43b68646f76d04a4ce8f,

title = "Microglia states and nomenclature: A field at its crossroads",

abstract = "Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as “resting versus activated” and “M1 versus M2.” This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.",

author = "Paolicelli, {Rosa C.} and Amanda Sierra and Beth Stevens and Marie-Eve Tremblay and Adriano Aguzzi and Bahareh Ajami and Ido Amit and Etienne Audinat and Ingo Bechmann and Mariko Bennett and Frederick Bennett and Alain Bessis and Knut Biber and Staci Bilbo and Mathew Blurton-Jones and Erik Boddeke and Dora Brites and Bert Br{\^o}ne and Brown, {Guy C.} and Oleg Butovsky and Carson, {Monica J.} and Bernardo Castellano and Marco Colonna and Cowley, {Sally A.} and Colm Cunningham and Dimitrios Davalos and {De Jager}, {Philip L.} and {de Strooper}, Bart and Adam Denes and Eggen, {Bart J.L.} and Ukpong Eyo and Elena Galea and Sonia Garel and Florent Ginhoux and Glass, {Christopher K.} and Ozgun Gokce and Diego Gomez-Nicola and Berta Gonz{\'a}lez and Siamon Gordon and Graeber, {Manuel B.} and Greenhalgh, {Andrew D.} and Pierre Gressens and Melanie Greter and Gutmann, {David H.} and Christian Haass and Heneka, {Michael T.} and Heppner, {Frank L.} and Soyon Hong and Hume, {David A.} and Steffen Jung and Helmut Kettenmann and Jonathan Kipnis and Ryuta Koyama and Greg Lemke and Marina Lynch and Ania Majewska and Marzia Malcangio and Tarja Malm and Renzo Mancuso and Takahiro Masuda and Michela Matteoli and McColl, {Barry W.} and Miron, {Veronique E.} and Molofsky, {Anna Victoria} and Michelle Monje and Eva Mracsko and Agnes Nadjar and Neher, {Jonas J.} and Urte Neniskyte and Harald Neumann and Mami Noda and Bo Peng and Francesca Peri and Perry, {V. Hugh} and Popovich, {Phillip G.} and Clare Pridans and Josef Priller and Marco Prinz and Davide Ragozzino and Ransohoff, {Richard M.} and Salter, {Michael W.} and Anne Schaefer and Schafer, {Dorothy P.} and Michal Schwartz and Mikael Simons and Smith, {Cody J.} and Streit, {Wolfgang J.} and Tay, {Tuan Leng} and Li-Huei Tsai and Alexei Verkhratsky and {von Bernhardi}, Rommy and Hiroaki Wake and Val{\'e}rie Wittamer and Wolf, {Susanne A.} and Long-Jun Wu and Tony Wyss-Coray",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = nov,

day = "2",

doi = "10.1016/j.neuron.2022.10.020",

language = "الإنجليزيّة",

volume = "110",

pages = "3458--3483",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "21",

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Paolicelli, RC, Sierra, A, Stevens, B, Tremblay, M-E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, GC, Butovsky, O, Carson, MJ, Castellano, B, Colonna, M, Cowley, SA, Cunningham, C, Davalos, D, De Jager, PL, de Strooper, B, Denes, A, Eggen, BJL, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, CK, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, MB, Greenhalgh, AD, Gressens, P, Greter, M, Gutmann, DH, Haass, C, Heneka, MT, Heppner, FL, Hong, S, Hume, DA, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, BW, Miron, VE, Molofsky, AV, Monje, M, Mracsko, E, Nadjar, A, Neher, JJ, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, VH, Popovich, PG, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, RM, Salter, MW, Schaefer, A, Schafer, DP, Schwartz, M, Simons, M, Smith, CJ, Streit, WJ, Tay, TL, Tsai, L-H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, SA, Wu, L-J & Wyss-Coray, T 2022, 'Microglia states and nomenclature: A field at its crossroads', Neuron, vol. 110, no. 21, pp. 3458-3483. https://doi.org/10.1016/j.neuron.2022.10.020

TY - JOUR

T1 - Microglia states and nomenclature

T2 - A field at its crossroads

AU - Paolicelli, Rosa C.

AU - Sierra, Amanda

AU - Stevens, Beth

AU - Tremblay, Marie-Eve

AU - Aguzzi, Adriano

AU - Ajami, Bahareh

AU - Amit, Ido

AU - Audinat, Etienne

AU - Bechmann, Ingo

AU - Bennett, Mariko

AU - Bennett, Frederick

AU - Bessis, Alain

AU - Biber, Knut

AU - Bilbo, Staci

AU - Blurton-Jones, Mathew

AU - Boddeke, Erik

AU - Brites, Dora

AU - Brône, Bert

AU - Brown, Guy C.

AU - Butovsky, Oleg

AU - Carson, Monica J.

AU - Castellano, Bernardo

AU - Colonna, Marco

AU - Cowley, Sally A.

AU - Cunningham, Colm

AU - Davalos, Dimitrios

AU - De Jager, Philip L.

AU - de Strooper, Bart

AU - Denes, Adam

AU - Eggen, Bart J.L.

AU - Eyo, Ukpong

AU - Galea, Elena

AU - Garel, Sonia

AU - Ginhoux, Florent

AU - Glass, Christopher K.

AU - Gokce, Ozgun

AU - Gomez-Nicola, Diego

AU - González, Berta

AU - Gordon, Siamon

AU - Graeber, Manuel B.

AU - Greenhalgh, Andrew D.

AU - Gressens, Pierre

AU - Greter, Melanie

AU - Gutmann, David H.

AU - Haass, Christian

AU - Heneka, Michael T.

AU - Heppner, Frank L.

AU - Hong, Soyon

AU - Hume, David A.

AU - Jung, Steffen

AU - Kettenmann, Helmut

AU - Kipnis, Jonathan

AU - Koyama, Ryuta

AU - Lemke, Greg

AU - Lynch, Marina

AU - Majewska, Ania

AU - Malcangio, Marzia

AU - Malm, Tarja

AU - Mancuso, Renzo

AU - Masuda, Takahiro

AU - Matteoli, Michela

AU - McColl, Barry W.

AU - Miron, Veronique E.

AU - Molofsky, Anna Victoria

AU - Monje, Michelle

AU - Mracsko, Eva

AU - Nadjar, Agnes

AU - Neher, Jonas J.

AU - Neniskyte, Urte

AU - Neumann, Harald

AU - Noda, Mami

AU - Peng, Bo

AU - Peri, Francesca

AU - Perry, V. Hugh

AU - Popovich, Phillip G.

AU - Pridans, Clare

AU - Priller, Josef

AU - Prinz, Marco

AU - Ragozzino, Davide

AU - Ransohoff, Richard M.

AU - Salter, Michael W.

AU - Schaefer, Anne

AU - Schafer, Dorothy P.

AU - Schwartz, Michal

AU - Simons, Mikael

AU - Smith, Cody J.

AU - Streit, Wolfgang J.

AU - Tay, Tuan Leng

AU - Tsai, Li-Huei

AU - Verkhratsky, Alexei

AU - von Bernhardi, Rommy

AU - Wake, Hiroaki

AU - Wittamer, Valérie

AU - Wolf, Susanne A.

AU - Wu, Long-Jun

AU - Wyss-Coray, Tony

PY - 2022/11/2

Y1 - 2022/11/2

N2 - Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as “resting versus activated” and “M1 versus M2.” This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.

AB - Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as “resting versus activated” and “M1 versus M2.” This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.

UR - http://www.scopus.com/inward/record.url?scp=85140895591&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2022.10.020

DO - 10.1016/j.neuron.2022.10.020

M3 - مقالة مرجعية

C2 - 36327895

SN - 0896-6273

VL - 110

SP - 3458

EP - 3483

JO - Neuron

JF - Neuron

IS - 21

ER -

Microglia states and nomenclature: A field at its crossroads

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