Microglia Plasticity During Health and Disease: An Immunological Perspective

Anat Shemer, Daniel Erny, Steffen Jung, Marco Prinz

Research output: Contribution to journalReview articlepeer-review

Abstract

Microglia are macrophages of the central nervous system (CNS) that continuously scrutinize their environment for damage. They colonize the cephalic mesenchyme during embryogenesis and actively shape the developing neuronal network by immune-mediated mechanisms. Upon CNS maturation, microglia drastically change phenotype and function. During health, adult microglia contribute to homeostasis, but also the establishment and resolution of inflammatory conditions. Fulfillment of these distinct tasks requires these long-lived cells to accurately adjust to their changing environment. Deciphering microglia responsiveness to divergent stimuli is central to understanding this cell type and for eventual microglia manipulation to potentially reduce disease burden. Here we discuss new aspects of myeloid cell biology in general with special emphasis on the shifting role of microglia during establishment and protection of CNS integrity.

Original languageEnglish
Pages (from-to)614-624
Number of pages11
JournalTrends in Immunology
Volume36
Issue number10
DOIs
StatePublished - 1 Oct 2015

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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