Microfluidic Chip for Site-Specific Neuropharmacological Treatment and Activity Probing of 3D Neuronal "Optonet" Cultures

Anat Marom; Sanjeev Kumar Mahto; Erez Shor; Janna Tenenbaum-Katan; Josue Sznitman; Shy Shoham

doi:https://doi.org/10.1002/adhm.201400643

Microfluidic Chip for Site-Specific Neuropharmacological Treatment and Activity Probing of 3D Neuronal "Optonet" Cultures

Anat Marom, Sanjeev Kumar Mahto, Erez Shor, Janna Tenenbaum-Katan, Josue Sznitman, Shy Shoham

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The study introduces a "brain-on-a-chip" microfluidic platform that hosts brain-like 3D cultures ("optonets") whose activity and responses to flowing drugs are recorded optically. Optonets are viable, optically accessible 3D neural networks whose characteristics approximate cortical networks. The results demonstrate the ability to monitor complex 3D activity patterns during extended site-specific, reversible neuropharmacogical exposure, suggesting an interesting potential in drug screening.

Original language	English
Pages (from-to)	1478-1483
Number of pages	6
Journal	Advanced Healthcare Materials
Volume	4
Issue number	10
DOIs	https://doi.org/10.1002/adhm.201400643
State	Published - 15 Jul 2015

Keywords

3D cultures
Calcium imaging
Carbachol
Drug screening
Optogenetics

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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https://doi.org/10.1002/adhm.201400643

Cite this

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title = "Microfluidic Chip for Site-Specific Neuropharmacological Treatment and Activity Probing of 3D Neuronal {"}Optonet{"} Cultures",

abstract = "The study introduces a {"}brain-on-a-chip{"} microfluidic platform that hosts brain-like 3D cultures ({"}optonets{"}) whose activity and responses to flowing drugs are recorded optically. Optonets are viable, optically accessible 3D neural networks whose characteristics approximate cortical networks. The results demonstrate the ability to monitor complex 3D activity patterns during extended site-specific, reversible neuropharmacogical exposure, suggesting an interesting potential in drug screening.",

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author = "Anat Marom and Mahto, {Sanjeev Kumar} and Erez Shor and Janna Tenenbaum-Katan and Josue Sznitman and Shy Shoham",

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T1 - Microfluidic Chip for Site-Specific Neuropharmacological Treatment and Activity Probing of 3D Neuronal "Optonet" Cultures

AU - Marom, Anat

AU - Mahto, Sanjeev Kumar

AU - Shor, Erez

AU - Tenenbaum-Katan, Janna

AU - Sznitman, Josue

AU - Shoham, Shy

PY - 2015/7/15

Y1 - 2015/7/15

N2 - The study introduces a "brain-on-a-chip" microfluidic platform that hosts brain-like 3D cultures ("optonets") whose activity and responses to flowing drugs are recorded optically. Optonets are viable, optically accessible 3D neural networks whose characteristics approximate cortical networks. The results demonstrate the ability to monitor complex 3D activity patterns during extended site-specific, reversible neuropharmacogical exposure, suggesting an interesting potential in drug screening.

AB - The study introduces a "brain-on-a-chip" microfluidic platform that hosts brain-like 3D cultures ("optonets") whose activity and responses to flowing drugs are recorded optically. Optonets are viable, optically accessible 3D neural networks whose characteristics approximate cortical networks. The results demonstrate the ability to monitor complex 3D activity patterns during extended site-specific, reversible neuropharmacogical exposure, suggesting an interesting potential in drug screening.

KW - 3D cultures

KW - Calcium imaging

KW - Carbachol

KW - Drug screening

KW - Optogenetics

UR - http://www.scopus.com/inward/record.url?scp=84948065975&partnerID=8YFLogxK

U2 - https://doi.org/10.1002/adhm.201400643

DO - https://doi.org/10.1002/adhm.201400643

M3 - مقالة

SN - 2192-2640

VL - 4

SP - 1478

EP - 1483

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 10

ER -

Microfluidic Chip for Site-Specific Neuropharmacological Treatment and Activity Probing of 3D Neuronal "Optonet" Cultures

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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