@article{e41a82c7d01e47ff8650e5bb6f84d8d1,
title = "Microbiome diurnal rhythmicity and its impact on host physiology and disease risk",
abstract = "Host-microbiome interactions constitute key determinants of host physiology, while their dysregulation is implicated in a wide range of human diseases. The microbiome undergoes diurnal variation in composition and function, and this in turn drives oscillations in host gene expression and functions. In this review, we discuss the newest developments in understanding circadian host-microbiome interplays, and how they may be relevant in health and disease contexts. We summarize the molecular mechanisms by which the microbiome influences host function in a diurnal manner, and inversely describe how the host orchestrates circadian rhythmicity of the microbiome. Furthermore, we highlight the future perspectives and challenges in studying this new and exciting facet of host-microbiome interactions. Finally, we illustrate how the elucidation of the microbiome chronobiology may pave the way for novel therapeutic approaches.",
author = "Nobs, {Samuel Philip} and Timur Tuganbaev and Eran Elinav",
note = "We thank the Elinav Lab for fruitful discussions and apologize to those authors whose works could not be cited due to space limitations. S.P.N. was supported by an Early Postdoctoral Fellowship of the Swiss National Science Foundation and an EMBO Long‐term Fellowship. E.E. is supported by Y. and R. Ungar; the Abisch Frenkel Foundation for the Promotion of Life Sciences; the Gurwin Family Fund for Scientific Research; the Leona M. and Harry B. Helmsley Charitable Trust; the Crown Endowment Fund for Immunological Research; the Else Kroener Fresenius Foundation; the estate of J. Gitlitz; the estate of L. Hershkovich; the Benoziyo Endowment Fund for the Advancement of Science; the Adelis Foundation; J. L. and V. Schwartz; A. and G. Markovitz; A. and C. Adelson; the French National Center for Scientific Research (CNRS); D. L. Schwarz; The V.R. Schwartz Research Fellow Chair; L. Steinberg; J.N. Halpern; A. Edelheit, and by grants funded by the European Research Council; a Marie Curie Integration grant; the German–Israeli Foundation for Scientific Research and Development; the Israel Science Foundation; the Minerva Foundation; the Rising Tide Foundation; the Helmholtz Foundation; and the European Foundation for the Study of Diabetes. E.E. is a senior fellow, Canadian Institute of Advanced Research (CIFAR) and an international scholar, The Bill & Melinda Gates Foundation, and Howard Hughes Medical Institute (HHMI). Funding Y. and R. Ungar Gurwin Family Fund Crown Endowment Fund Else Kroener Fresenius Foundation Estate of J. Gitlitz Estate of L. Hershkovich Benoziyo Endowment Fund Adelis Foundation French National Center for Scientific Research (CNRS) European Research Council Marie Curie Integration grant Rising Tide Foundation Helmholtz Foundation J. L. and V. Schwartz A. and G. Markovitz A. and C. Adelson D. L. Schwarz The V.R. Schwartz Research Fellow Chair L. Steinberg J.N. Halpern A. Edelheit Early Postdoctoral Fellowship of the Swiss National Science Foundation Abisch Frenkel Foundation Leona M. and Harry B. Helmsley Charitable Trust German–Israeli Foundation for Scientific Research and Development Israel Science Foundation Minerva Foundation European Foundation for the Study of Diabetes",
year = "2019",
month = apr,
day = "1",
doi = "https://doi.org/10.15252/embr.201847129",
language = "الإنجليزيّة",
volume = "20",
journal = "EMBO Reports",
issn = "1469-221X",
publisher = "EMBO Press",
number = "4",
}