Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Ido Sagi; Shiran Bar; Nissim Benvenisty

doi:10.1016/j.stem.2018.10.012

Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Ido Sagi, Shiran Bar, Nissim Benvenisty

Department of Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Short survey › peer-review

Abstract

Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting. Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.

Original language	English
Pages (from-to)	625-627
Number of pages	3
Journal	Cell Stem Cell
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2018.10.012
State	Published - 1 Nov 2018

All Science Journal Classification (ASJC) codes

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2018.10.012

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abstract = "Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting. Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.",

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Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Abstract

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