MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy

Roni Bareli; Cyrille J. Cohen

doi:10.1080/2162402X.2016.1159370

MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy

Roni Bareli, Cyrille J. Cohen

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy.

Original language	English
Article number	e1159370
Journal	OncoImmunology
Volume	5
Issue number	7
DOIs	https://doi.org/10.1080/2162402X.2016.1159370
State	Published - 2 Jul 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Immunotherapy
MHC multimers
T-cells
TCR
neoantigens
tumor immunology

All Science Journal Classification (ASJC) codes

Oncology
Immunology and Allergy
Immunology

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10.1080/2162402X.2016.1159370

Cite this

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abstract = "Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy.",

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AB - Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy.

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KW - MHC multimers

KW - T-cells

KW - TCR

KW - neoantigens

KW - tumor immunology

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MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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