MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy

Roni Bareli, Cyrille J. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy.

Original languageEnglish
Article numbere1159370
JournalOncoImmunology
Volume5
Issue number7
DOIs
StatePublished - 2 Jul 2016

Keywords

  • Immunotherapy
  • MHC multimers
  • T-cells
  • TCR
  • neoantigens
  • tumor immunology

All Science Journal Classification (ASJC) codes

  • Oncology
  • Immunology and Allergy
  • Immunology

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