Abstract
Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy.
Original language | English |
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Article number | e1159370 |
Journal | OncoImmunology |
Volume | 5 |
Issue number | 7 |
DOIs | |
State | Published - 2 Jul 2016 |
Keywords
- Immunotherapy
- MHC multimers
- T-cells
- TCR
- neoantigens
- tumor immunology
All Science Journal Classification (ASJC) codes
- Oncology
- Immunology and Allergy
- Immunology