Methods of generating oligodendrocytes and cell populations comprising same

Shimon Slavin; Chaya Brodie

Methods of generating oligodendrocytes and cell populations comprising same

Shimon Slavin (Inventor), Chaya Brodie (Inventor)

The Mina and Everard Goodman Faculty of Life Sciences

Bar-Ilan University

Research output: Patent

Abstract

A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating the population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.

Original language	English
Patent number	US9783781B2
State	Published - 10 Oct 2017

Cite this

@misc{f9778603dde14fd29576b9e8d05aa6e7,

title = "Methods of generating oligodendrocytes and cell populations comprising same",

abstract = "A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating the population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.",

author = "Shimon Slavin and Chaya Brodie",

note = "US Patent 9,783,781; US9783781B2",

year = "2017",

month = oct,

day = "10",

language = "الإنجليزيّة",

type = "Patent",

}

TY - PAT

T1 - Methods of generating oligodendrocytes and cell populations comprising same

AU - Slavin, Shimon

AU - Brodie, Chaya

N1 - US Patent 9,783,781

PY - 2017/10/10

Y1 - 2017/10/10

N2 - A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating the population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.

AB - A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating the population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.

UR - https://patents.google.com/patent/US9783781B2/en

M3 - براءة الإختراع

M1 - US9783781B2

ER -

Methods of generating oligodendrocytes and cell populations comprising same

Abstract

Other files and links

Fingerprint

Cite this