Methods for the identification of sarm1 nadase activity inhibitors and uses thereof

The present disclosure provides screening methods for identifying a sterile α and HEAT/armadillo motif-containing protein-1 (SARM1) NADase modulator, specifically, inhibitor, using at least one full length or near full length catalytically active SARM1 or any fragment or variant thereof. The present disclosure further provides SARM inhibitors identified by the screening methods, and therapeutic compositions and methods for treating, conditions or disorders associated directly or indirectly with axonal and/or cellular degradation.