Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chun Cheih Chao; Cristina Gutiérrez-Vázquez; Veit Rothhammer; Lior Mayo; Michael A. Wheeler; Emily C. Tjon; Stephanie E.J. Zandee; Manon Blain; Kalil Alves de Lima; Maisa C. Takenaka; Julian Avila-Pacheco; Patrick Hewson; Lei Liu; Liliana M. Sanmarco; Davis M. Borucki; Gabriel Z. Lipof; Sunia A. Trauger; Clary B. Clish; Jack P. Antel; Alexandre Prat; Francisco J. Quintana

doi:10.1016/j.cell.2019.11.016

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chun Cheih Chao, Cristina Gutiérrez-Vázquez, Veit Rothhammer, Lior Mayo, Michael A. Wheeler, Emily C. Tjon, Stephanie E.J. Zandee, Manon Blain, Kalil Alves de Lima, Maisa C. Takenaka, Julian Avila-Pacheco, Patrick Hewson, Lei Liu, Liliana M. Sanmarco, Davis M. Borucki, Gabriel Z. Lipof, Sunia A. Trauger, Clary B. Clish, Jack P. Antel, Alexandre PratFrancisco J. Quintana

Department of Cell Research and Immunology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.

Original language	English
Pages (from-to)	1483-1498.e22
Journal	Cell
Volume	179
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2019.11.016
State	Published - 12 Dec 2019

Keywords

MAVS
Miglustat
NF-κB
astrocytes
cPLA2
lactate
lactosylceramide
metabolism
multiple sclerosis
neuroinflammation

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cell.2019.11.016

Cite this

Chao, C. C., Gutiérrez-Vázquez, C., Rothhammer, V., Mayo, L., Wheeler, M. A., Tjon, E. C., Zandee, S. E. J., Blain, M., de Lima, K. A., Takenaka, M. C., Avila-Pacheco, J., Hewson, P., Liu, L., Sanmarco, L. M., Borucki, D. M., Lipof, G. Z., Trauger, S. A., Clish, C. B., Antel, J. P., ... Quintana, F. J. (2019). Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell, 179(7), 1483-1498.e22. https://doi.org/10.1016/j.cell.2019.11.016

@article{6c30c5cb07604683a50ade8a83a7b4ff,

title = "Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS",

abstract = "By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.",

keywords = "MAVS, Miglustat, NF-κB, astrocytes, cPLA2, lactate, lactosylceramide, metabolism, multiple sclerosis, neuroinflammation",

author = "Chao, \{Chun Cheih\} and Cristina Guti{\'e}rrez-V{\'a}zquez and Veit Rothhammer and Lior Mayo and Wheeler, \{Michael A.\} and Tjon, \{Emily C.\} and Zandee, \{Stephanie E.J.\} and Manon Blain and \{de Lima\}, \{Kalil Alves\} and Takenaka, \{Maisa C.\} and Julian Avila-Pacheco and Patrick Hewson and Lei Liu and Sanmarco, \{Liliana M.\} and Borucki, \{Davis M.\} and Lipof, \{Gabriel Z.\} and Trauger, \{Sunia A.\} and Clish, \{Clary B.\} and Antel, \{Jack P.\} and Alexandre Prat and Quintana, \{Francisco J.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

day = "12",

doi = "10.1016/j.cell.2019.11.016",

language = "الإنجليزيّة",

volume = "179",

pages = "1483--1498.e22",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "7",

}

Chao, CC, Gutiérrez-Vázquez, C, Rothhammer, V, Mayo, L, Wheeler, MA, Tjon, EC, Zandee, SEJ, Blain, M, de Lima, KA, Takenaka, MC, Avila-Pacheco, J, Hewson, P, Liu, L, Sanmarco, LM, Borucki, DM, Lipof, GZ, Trauger, SA, Clish, CB, Antel, JP, Prat, A & Quintana, FJ 2019, 'Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS', Cell, vol. 179, no. 7, pp. 1483-1498.e22. https://doi.org/10.1016/j.cell.2019.11.016

TY - JOUR

T1 - Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

AU - Chao, Chun Cheih

AU - Gutiérrez-Vázquez, Cristina

AU - Rothhammer, Veit

AU - Mayo, Lior

AU - Wheeler, Michael A.

AU - Tjon, Emily C.

AU - Zandee, Stephanie E.J.

AU - Blain, Manon

AU - de Lima, Kalil Alves

AU - Takenaka, Maisa C.

AU - Avila-Pacheco, Julian

AU - Hewson, Patrick

AU - Liu, Lei

AU - Sanmarco, Liliana M.

AU - Borucki, Davis M.

AU - Lipof, Gabriel Z.

AU - Trauger, Sunia A.

AU - Clish, Clary B.

AU - Antel, Jack P.

AU - Prat, Alexandre

AU - Quintana, Francisco J.

PY - 2019/12/12

Y1 - 2019/12/12

N2 - By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.

AB - By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.

KW - MAVS

KW - Miglustat

KW - NF-κB

KW - astrocytes

KW - cPLA2

KW - lactate

KW - lactosylceramide

KW - metabolism

KW - multiple sclerosis

KW - neuroinflammation

UR - http://www.scopus.com/inward/record.url?scp=85076153358&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.11.016

DO - 10.1016/j.cell.2019.11.016

M3 - مقالة

SN - 0092-8674

VL - 179

SP - 1483-1498.e22

JO - Cell

JF - Cell

IS - 7

ER -

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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