TY - JOUR
T1 - Metabolic abnormalities in the hippocampus of patients with schizophrenia
T2 - A 3D multivoxel MR spectroscopic imaging study at 3T
AU - Meyer, E. J.
AU - Kirov, I. I.
AU - Tal, A.
AU - Davitz, M. S.
AU - Babb, J. S.
AU - Lazar, M.
AU - Malaspina, D.
AU - Gonen, O.
N1 - National Institutes of Health [RC1MH088843, 2K24MH00169, MH108962, EB011639, EB01015, NS081772, NS090417, NS097494]; Center for Advanced Imaging Innovation and Research; National Institute of Biomedical Imaging and Bioengineering Biomedical Technology Resource Center (NIH) [P41 EB017183]; CTSI [UUTR000038]; Monroy-Marks Career Development Fund; Carolito Stiftung Fund; Leona M. and Harry B. Helmsley Charitable Trust; historic generosity of the Harold Perlman Family; Sylvia Schaefer Alzheimer's Research Fund This work was supported by National Institutes of Health grants: RC1MH088843, 2K24MH00169, MH108962, EB011639, EB01015, NS081772, NS090417, NS097494; and the Center for Advanced Imaging Innovation and Research (www.cai2r.net), a National Institute of Biomedical Imaging and Bioengineering Biomedical Technology Resource Center (NIH P41 EB017183) and CTSI UUTR000038 (New York University). Assaf Tat acknowledges the support of the Monroy-Marks Career Development Fund, the Carolito Stiftung Fund, the Leona M. and Harry B. Helmsley Charitable Trust, and the historic generosity of the Harold Perlman Family. This research was supported by a research grant from the Sylvia Schaefer Alzheimer's Research Fund.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - BACKGROUNDANDPURPOSE: Schizophrenia is well-known to be associated with hippocampal structural abnormalities.Weused 1H-MR spectroscopy to test the hypothesis that these abnormalities are accompanied by NAA deficits, reflecting neuronal dysfunction, in patients compared with healthy controls. MATERIALS AND METHODS: Nineteen patients with schizophrenia (11 men; mean age, 40.6±10.1 years; mean disease duration, 19.5±10.5 years) and 11 matched healthy controls (5 men; mean age, 33.7 ± 10.1 years) underwent MR imaging and multivoxel point-resolved spectroscopy (TE/TR, 35/1400 ms) 1H-MRS at 3T to obtain their hippocampalGMabsolute NAA, Cr, Cho, and mIns concentrations. Unequal variance t tests and ANCOVA were used to compare patients with controls. Bilateral volumes from manually outlined hippocampal masks were compared by using unequal variance t tests. RESULTS: Patients' average hippocampal GM Cr concentrations were 19% higher than that of controls, 8.7 ± 2.2 versus 7.4 ± 1.2 mmol/L (P≤.05); showing no differences, concentrations in NAA were 8.8±1.6 versus 8.7±1.2 mmol/L; in Cho, 2.3±0.7 versus 2.1±0.3 mmol/L; and in mIns, 6.1±1.5 versus 5.2±0.9 (all P≤.1). There was a positive correlation between mIns and Cr in patients (r=0.57, P≤.05) but not in controls. The mean bilateral hippocampal volume was 10% lower in patients: 7.5 ± 0.9 versus 8.4± 0.7 cm3 (P ≤ .05). CONCLUSIONS: These findings suggest that the hippocampal volume deficit in schizophrenia is not due to net loss of neurons, in agreement with histopathology studies but not with prior 1H-MR spectroscopy reports. Elevated Cr is consistent with hippocampal hypermetabolism, and its correlation with mIns may also suggest an inflammatory process affecting some cases; these findings may suggest treatment targets and markers to monitor them.
AB - BACKGROUNDANDPURPOSE: Schizophrenia is well-known to be associated with hippocampal structural abnormalities.Weused 1H-MR spectroscopy to test the hypothesis that these abnormalities are accompanied by NAA deficits, reflecting neuronal dysfunction, in patients compared with healthy controls. MATERIALS AND METHODS: Nineteen patients with schizophrenia (11 men; mean age, 40.6±10.1 years; mean disease duration, 19.5±10.5 years) and 11 matched healthy controls (5 men; mean age, 33.7 ± 10.1 years) underwent MR imaging and multivoxel point-resolved spectroscopy (TE/TR, 35/1400 ms) 1H-MRS at 3T to obtain their hippocampalGMabsolute NAA, Cr, Cho, and mIns concentrations. Unequal variance t tests and ANCOVA were used to compare patients with controls. Bilateral volumes from manually outlined hippocampal masks were compared by using unequal variance t tests. RESULTS: Patients' average hippocampal GM Cr concentrations were 19% higher than that of controls, 8.7 ± 2.2 versus 7.4 ± 1.2 mmol/L (P≤.05); showing no differences, concentrations in NAA were 8.8±1.6 versus 8.7±1.2 mmol/L; in Cho, 2.3±0.7 versus 2.1±0.3 mmol/L; and in mIns, 6.1±1.5 versus 5.2±0.9 (all P≤.1). There was a positive correlation between mIns and Cr in patients (r=0.57, P≤.05) but not in controls. The mean bilateral hippocampal volume was 10% lower in patients: 7.5 ± 0.9 versus 8.4± 0.7 cm3 (P ≤ .05). CONCLUSIONS: These findings suggest that the hippocampal volume deficit in schizophrenia is not due to net loss of neurons, in agreement with histopathology studies but not with prior 1H-MR spectroscopy reports. Elevated Cr is consistent with hippocampal hypermetabolism, and its correlation with mIns may also suggest an inflammatory process affecting some cases; these findings may suggest treatment targets and markers to monitor them.
UR - https://www.scopus.com/pages/publications/85006390492
U2 - 10.3174/ajnr.A4886
DO - 10.3174/ajnr.A4886
M3 - مقالة
C2 - 27444940
SN - 0195-6108
VL - 37
SP - 2273
EP - 2279
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 12
ER -