“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells

Chamutal Gur; Ofer Mandelboim; Gilad Bachrach

doi:10.1080/2162402X.2015.1038690

“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells

Chamutal Gur, Ofer Mandelboim, Gilad Bachrach

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	OncoImmunology
Volume	4
Issue number	9
DOIs	https://doi.org/10.1080/2162402X.2015.1038690
State	Published - 1 Jan 2015

Keywords

Colon adenocarcinoma
Fusobacteria
NK cells
Tumor immunity

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/2162402X.2015.1038690

Cite this

@article{ee9c957efa804035a930199c0dc6e6d7,

title = "“Messieurs, c{\textquoteright}est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells",

abstract = "Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.",

keywords = "Colon adenocarcinoma, Fusobacteria, NK cells, Tumor immunity",

author = "Chamutal Gur and Ofer Mandelboim and Gilad Bachrach",

note = "Publisher Copyright: {\textcopyright} 2015 Taylor \& Francis Group, LLC.",

year = "2015",

month = jan,

day = "1",

doi = "10.1080/2162402X.2015.1038690",

language = "الإنجليزيّة",

volume = "4",

pages = "1--3",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "9",

}

“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells. / Gur, Chamutal; Mandelboim, Ofer ; Bachrach, Gilad.
In: OncoImmunology, Vol. 4, No. 9, 01.01.2015, p. 1-3.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - “Messieurs, c’est les microbes qui auront le dernier mot”

T2 - Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells

AU - Gur, Chamutal

AU - Mandelboim, Ofer

AU - Bachrach, Gilad

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

AB - Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

KW - Colon adenocarcinoma

KW - Fusobacteria

KW - NK cells

KW - Tumor immunity

UR - http://www.scopus.com/inward/record.url?scp=84944449056&partnerID=8YFLogxK

U2 - 10.1080/2162402X.2015.1038690

DO - 10.1080/2162402X.2015.1038690

M3 - مقالة

SN - 2162-4011

VL - 4

SP - 1

EP - 3

JO - OncoImmunology

JF - OncoImmunology

IS - 9

ER -

“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this