Messenger RNA Translation Defects in Neurodegenerative Diseases.

Erik Storkebaum; Kobi Rosenblum; Nahum Sonenberg

doi:10.1056/nejmra2215795

Messenger RNA Translation Defects in Neurodegenerative Diseases.

Erik Storkebaum, Kobi Rosenblum, Nahum Sonenberg

Department of Neurobiology

University of Haifa

Research output: Contribution to journal › Article › peer-review

Abstract

Translation Defects in Neurodegenerative Diseases Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.

Original language	American English
Pages (from-to)	1015-1030
Number of pages	16
Journal	New England Journal of Medicine
Volume	388
Issue number	11
DOIs	https://doi.org/10.1056/nejmra2215795
State	Published - 16 Mar 2023

Keywords

Amyotrophic Lateral Sclerosis
Dementia/Alzheimer Disease
Genetics
Neurology/Neurosurgery
Neuromuscular Disease
Neuroscience
Parkinson Disease

All Science Journal Classification (ASJC) codes

General Medicine

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10.1056/nejmra2215795

Cite this

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title = "Messenger RNA Translation Defects in Neurodegenerative Diseases.",

abstract = "Translation Defects in Neurodegenerative Diseases Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.",

keywords = "Amyotrophic Lateral Sclerosis, Dementia/Alzheimer Disease, Genetics, Neurology/Neurosurgery, Neuromuscular Disease, Neuroscience, Parkinson Disease",

author = "Erik Storkebaum and Kobi Rosenblum and Nahum Sonenberg",

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AU - Rosenblum, Kobi

AU - Sonenberg, Nahum

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AB - Translation Defects in Neurodegenerative Diseases Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.

KW - Amyotrophic Lateral Sclerosis

KW - Dementia/Alzheimer Disease

KW - Genetics

KW - Neurology/Neurosurgery

KW - Neuromuscular Disease

KW - Neuroscience

KW - Parkinson Disease

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DO - 10.1056/nejmra2215795

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

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ER -

Messenger RNA Translation Defects in Neurodegenerative Diseases.

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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