Mechanisms of node of Ranvier assembly

Matthew N. Rasband, Elior Peles

Research output: Contribution to journalReview articlepeer-review


The nodes of Ranvier have clustered Na+ and K+ channels necessary for rapid and efficient axonal action potential conduction. However, detailed mechanisms of channel clustering have only recently been identified: they include two independent axon–glia interactions that converge on distinct axonal cytoskeletons. Here, we discuss how glial cell adhesion molecules and the extracellular matrix molecules that bind them assemble combinations of ankyrins, spectrins and other cytoskeletal scaffolding proteins, which cluster ion channels. We present a detailed molecular model, incorporating these overlapping mechanisms, to explain how the nodes of Ranvier are assembled in both the peripheral and central nervous systems.

Original languageEnglish
Pages (from-to)7-20
Number of pages14
JournalNature Reviews Neuroscience
Issue number1
Early online date25 Nov 2020
StatePublished - Jan 2021

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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