Mechanism and medical implications of mammalian autophagy

Ivan Dikic, Zvulun Elazar

Research output: Contribution to journalReview articlepeer-review

Abstract

Autophagy is a highly conserved catabolic process induced under various conditions of cellular stress, which prevents cell damage and promotes survival in the event of energy or nutrient shortage and responds to various cytotoxic insults. Thus, autophagy has primarily cytoprotective functions and needs to be tightly regulated to respond correctly to the different stimuli that cells experience, thereby conferring adaptation to the ever-changing environment. It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.

Original languageEnglish
Pages (from-to)349-364
Number of pages16
JournalNature Reviews Molecular Cell Biology
Volume19
Issue number6
Early online date4 Apr 2018
DOIs
StatePublished - Jun 2018

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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