TY - JOUR
T1 - Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation
AU - Jeltsch, Albert
AU - Ehrenhofer-Murray, Ann
AU - Jurkowski, Tomasz P.
AU - Lyko, Frank
AU - Reuter, Gunter
AU - Ankri, Serge
AU - Nellen, Wolfgang
AU - Schaefer, Matthias
AU - Helm, Mark
N1 - Publisher Copyright: © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC © 2017, © Albert Jeltsch, Ann Ehrenhofer-Murray, Tomasz P. Jurkowski, Frank Lyko, Gunter Reuter, Serge Ankri, Wolfgang Nellen, Matthias Schaefer, and Mark Helm.
PY - 2017/9/2
Y1 - 2017/9/2
N2 - A group of homologous nucleic acid modification enzymes called Dnmt2, Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a methyl group from the cofactor S-adenosyl-methionine (SAM) to the carbon-5 of cytosine residues. Originally considered as DNA MTases, these enzymes were shown to be tRNA methyltransferases about a decade ago. Between the presumed involvement in DNA modification-related epigenetics, and the recent foray into the RNA modification field, significant progress has characterized Dnmt2-related research. Here, we review this progress in its diverse facets including molecular evolution, structural biology, biochemistry, chemical biology, cell biology and epigenetics.
AB - A group of homologous nucleic acid modification enzymes called Dnmt2, Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a methyl group from the cofactor S-adenosyl-methionine (SAM) to the carbon-5 of cytosine residues. Originally considered as DNA MTases, these enzymes were shown to be tRNA methyltransferases about a decade ago. Between the presumed involvement in DNA modification-related epigenetics, and the recent foray into the RNA modification field, significant progress has characterized Dnmt2-related research. Here, we review this progress in its diverse facets including molecular evolution, structural biology, biochemistry, chemical biology, cell biology and epigenetics.
KW - DNA methylation
KW - RNA methylation
KW - epigenetics
KW - methylcytidine
KW - tRNA
UR - http://www.scopus.com/inward/record.url?scp=84976534043&partnerID=8YFLogxK
U2 - 10.1080/15476286.2016.1191737
DO - 10.1080/15476286.2016.1191737
M3 - مقالة مرجعية
SN - 1547-6286
VL - 14
SP - 1108
EP - 1123
JO - RNA Biology
JF - RNA Biology
IS - 9
ER -