Matrix-assisted peptide synthesis on nanoparticles

Raz Khandadash, Victoria Machtey, Aryeh Weiss, Gerardo Byk

Research output: Contribution to journalArticlepeer-review


We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides.

Original languageEnglish
Pages (from-to)675-679
Number of pages5
JournalJournal of Peptide Science
Issue number9
StatePublished - Sep 2014


  • embedded nanoparticle
  • magnetic matrix
  • nanoparticle
  • peptide
  • solid phase peptide synthesis

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry


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