Matrix-assisted peptide synthesis on nanoparticles

Raz Khandadash; Victoria Machtey; Aryeh Weiss; Gerardo Byk

doi:https://doi.org/10.1002/psc.2664

Matrix-assisted peptide synthesis on nanoparticles

Raz Khandadash, Victoria Machtey, Aryeh Weiss, Gerardo Byk

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides.

Original language	English
Pages (from-to)	675-679
Number of pages	5
Journal	Journal of Peptide Science
Volume	20
Issue number	9
DOIs	https://doi.org/10.1002/psc.2664
State	Published - Sep 2014

Keywords

embedded nanoparticle
magnetic matrix
nanoparticle
peptide
solid phase peptide synthesis

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Organic Chemistry

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https://doi.org/10.1002/psc.2664

Cite this

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title = "Matrix-assisted peptide synthesis on nanoparticles",

abstract = "We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides.",

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author = "Raz Khandadash and Victoria Machtey and Aryeh Weiss and Gerardo Byk",

year = "2014",

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AU - Khandadash, Raz

AU - Machtey, Victoria

AU - Weiss, Aryeh

AU - Byk, Gerardo

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N2 - We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides.

AB - We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides.

KW - embedded nanoparticle

KW - magnetic matrix

KW - nanoparticle

KW - peptide

KW - solid phase peptide synthesis

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DO - https://doi.org/10.1002/psc.2664

M3 - مقالة

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VL - 20

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JO - Journal of Peptide Science

JF - Journal of Peptide Science

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ER -

Matrix-assisted peptide synthesis on nanoparticles

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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