Abstract
Objective
Maternal obesity rates have increased dramatically over the last 3 decades, along with the associated chronic illnesses including cardiovascular diseases. We aimed to investigate a possible association between maternal obesity (BMI>30) and the long-term risk for cardiovascular diseases in the offspring during a follow- up period of up to 18 years.
Study Design
A population based cohort analysis was performed comparing both total as well as different subtypes of cardiovascular morbidity leading to hospitalization among children (up to the age of 18 years) in obese and non-obese mothers. Data on pregnancy course and outcome, mode of delivery, and later offspring hospitalizations were collected from two different databases in a single regional tertiary medical center. All singleton deliveries between the years 1991-2014 were included in the analysis. Exclusion criteria were congenital malformations. Kaplan-Meier survival curve was constructed to compare cumulative cardiovascular related hospitalization incidence stratified by maternal obesity, and a Weibull survival hazard model was used to control for confounders.
Results
During the study period, 242,342 newborns met the inclusion criteria: 3,290 were born to obese mothers, and 239,052 to non-obese mothers. During the follow up period (0-18 years, median 10.53), 36 (1.1%) versus 1,467 (0.6%) were hospitalized (at least once) due to cardiovascular morbidity among the obese and non-obese mothers, respectively (OR= 1.8, 95%CI 1.3-2.5; Log rank p=0.002, Figure). Selected categories of cardiovascular morbidity are presented in the Table. The association between maternal obesity and long-term pediatric cardiovascular morbidity remained significant in the Weibull hazards model controlled for maternal age, gestational age, pregnancy related diabetes and hypertension (adjusted HR 1.8; 95% CI 1.3-2.4).
Conclusion
Maternal obesity is independently associated with an increased risk for offspring pediatric cardiovascular morbidity.
Maternal obesity rates have increased dramatically over the last 3 decades, along with the associated chronic illnesses including cardiovascular diseases. We aimed to investigate a possible association between maternal obesity (BMI>30) and the long-term risk for cardiovascular diseases in the offspring during a follow- up period of up to 18 years.
Study Design
A population based cohort analysis was performed comparing both total as well as different subtypes of cardiovascular morbidity leading to hospitalization among children (up to the age of 18 years) in obese and non-obese mothers. Data on pregnancy course and outcome, mode of delivery, and later offspring hospitalizations were collected from two different databases in a single regional tertiary medical center. All singleton deliveries between the years 1991-2014 were included in the analysis. Exclusion criteria were congenital malformations. Kaplan-Meier survival curve was constructed to compare cumulative cardiovascular related hospitalization incidence stratified by maternal obesity, and a Weibull survival hazard model was used to control for confounders.
Results
During the study period, 242,342 newborns met the inclusion criteria: 3,290 were born to obese mothers, and 239,052 to non-obese mothers. During the follow up period (0-18 years, median 10.53), 36 (1.1%) versus 1,467 (0.6%) were hospitalized (at least once) due to cardiovascular morbidity among the obese and non-obese mothers, respectively (OR= 1.8, 95%CI 1.3-2.5; Log rank p=0.002, Figure). Selected categories of cardiovascular morbidity are presented in the Table. The association between maternal obesity and long-term pediatric cardiovascular morbidity remained significant in the Weibull hazards model controlled for maternal age, gestational age, pregnancy related diabetes and hypertension (adjusted HR 1.8; 95% CI 1.3-2.4).
Conclusion
Maternal obesity is independently associated with an increased risk for offspring pediatric cardiovascular morbidity.
| Original language | American English |
|---|---|
| Pages (from-to) | S438-S438 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 218 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2018 |
