Abstract
Drug allergy is associated with adverse short-term perinatal outcomes such as caesarian delivery and preterm delivery. The aim of the present study was to determine whether being born to a mother with known drug allergy increases the risk for long-term dermatological morbidity of the offspring. A population-based cohort study, comparing long-term dermatological morbidity of offspring to mothers with and without known drug allergy, was conducted. Dermatological morbidity was assessed up to the age of 18 years according to a predefined set of ICD-9 codes associated with hospitalization of the offspring. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term dermatological morbidity, and a Cox proportional hazards model was constructed to control of confounders. During the study period, 243,682 deliveries met the inclusion criteria, of them 4% (n = 9756) were of mothers with known drug allergy. Offspring born to mothers with known drug allergy had higher rates of long-term dermatological morbidity Likewise, the cumulative incidence of long-term dermatological morbidity was higher as compared with those without known drug allergy (Kaplan-Meier log-rank P =.021). Using a Cox proportional hazards model, controlling for confounders, being born to a mother with known drug allergy was found to be an independent risk factor for long-term dermatological morbidity of the offspring (adjusted HR 1.2, 95% CI 1.03-1.33, P =.016). Being born to a mother with known drug allergy is independently associated with higher risk for long-term dermatological morbidity of the offspring.
Original language | American English |
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Article number | e13356 |
Journal | American Journal of Reproductive Immunology |
Volume | 85 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2021 |
Keywords
- dermatological morbidities
- drug allergy
- offspring
- pregnancy outcomes
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Reproductive Medicine
- Obstetrics and Gynaecology