Maternal chorioamnionitis & long term neurological morbidity in the offspring

Amir Freud, Tamar Wainstock, Eyal Sheiner, Ron Beloosesky, Laura Fischer, Daniella Landau, Asnat Walfisch

Research output: Contribution to journalArticlepeer-review


Background: Chorioamnionitis is a common and potentially devastating complication of pregnancy associated with maternal and perinatal adverse outcomes. Objective: To evaluate a possible association between maternal chorioamnionitis and long-term pediatric neurological morbidity. Study design: A population-based retrospective cohort analysis was performed comparing the risk of long-term neurological morbidity. Pediatric neurological morbidity evaluated included hospitalizations with neurological morbidity. Kaplan–Meier survival curves were constructed to compare the cumulative neurological morbidity and a Cox regression model was used to control for confounders. Results: 238 622 newborns were included. Of them, 0.5% were born to mothers with chorioamnionitis. 3.1% offspring were hospitalized with a neurological condition. Total neurological morbidity was not significantly more common in the chorioamnionitis group (3.8% vs. 3.1% respectively, OR 1.23, 95% CI 0.9–1.6, p = 0.147). However, a significant and independent association was noted between maternal chorioamnionitis and cerebral palsy. (0.5% vs. 0.1%, OR 5.77, 95% CI 2.5–13.0, p = 0.001). In a Cox proportional hazards model, controlling for preterm delivery, birthweight, maternal factors and mode of delivery the association between chorioamnionitis and cerebral palsy remained significant (adjusted HR = 2.78, 95% CI 1.20–6.43, P = 0.016). Conclusion: Maternal chorioamnionitis is associated with cerebral palsy in the offspring, independently of other birth circumstances such as preterm delivery and birthweight.

Original languageAmerican English
Pages (from-to)484-490
Number of pages7
JournalEuropean Journal of Paediatric Neurology
Issue number3
StatePublished - 1 May 2019


  • Cerebral palsy
  • Developmental delay
  • Intra-amniotic infection
  • Outcome
  • Pregnancy

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health


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