Mark/Par-1 marking the polarity of migrating neurons

Orly Reiner; Tamar Sapir

doi:https://doi.org/10.1007/978-94-7-7687-6_6

Mark/Par-1 marking the polarity of migrating neurons

Orly Reiner, Tamar Sapir

Department of Molecular Genetics

Weizmann Institute of Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Proper brain development requires the orchestrated migration of neurons from their place of birth to their final positioning, where they will form appropriate connections with their target cells. These events require coordinated activity of multiple elements of the cytoskeleton, in which the MARK/Par-1 polarity kinase plays an important role. Here, the various roles and modes of regulation of MARK/Par-1 are reviewed. MARK/Par-1 participates in axon formation in primary hippocampal neurons. Balanced levels of MARK/Par-1 are required for proper radial migration, as well as for migration in the rostral migratory stream. Normal neuronal migration requires at least two of MARK/Par-1 substrates, DCX and tau. Overall, the positioning of MARK/Par-1 at the crosstalk of regulating cytoskeletal dynamics allows its participation in neuronal polarity decisions.

Original language	English
Title of host publication	Cellular and Molecular Control of Neuronal Migration
Publisher	Springer Verlag
Pages	97-111
Number of pages	15
ISBN (Print)	9789400776869
DOIs	https://doi.org/10.1007/978-94-7-7687-6_6
State	Published - 2014

Publication series

Name	Advances in Experimental Medicine and Biology

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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https://doi.org/10.1007/978-94-7-7687-6_6

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AB - Proper brain development requires the orchestrated migration of neurons from their place of birth to their final positioning, where they will form appropriate connections with their target cells. These events require coordinated activity of multiple elements of the cytoskeleton, in which the MARK/Par-1 polarity kinase plays an important role. Here, the various roles and modes of regulation of MARK/Par-1 are reviewed. MARK/Par-1 participates in axon formation in primary hippocampal neurons. Balanced levels of MARK/Par-1 are required for proper radial migration, as well as for migration in the rostral migratory stream. Normal neuronal migration requires at least two of MARK/Par-1 substrates, DCX and tau. Overall, the positioning of MARK/Par-1 at the crosstalk of regulating cytoskeletal dynamics allows its participation in neuronal polarity decisions.

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ER -

Mark/Par-1 marking the polarity of migrating neurons

Abstract

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